乳腺癌转移相关基因的文献计量分析  

A bibliometric analysis of breast cancer metastatic genes

作　　者：谢菲[1] 黄东兰[1] 岑东芝[1] 张积仁[1] 

机构地区：[1]南方医科大学附属珠江医院肿瘤中心,广州510282

出　　处：《重庆医学》2012年第5期420-422,425,共4页Chongqing medicine

摘　　要：目的了解近10年来乳腺癌转移相关基因的研究概况,寻找未来的研究方向。方法文献检索数据库为Embase、Medline/Pubmed及BIOSIS Preview 3个数据库。文献检索年限为2001年1月至2010年12月,对最终纳入的363篇文献的出版年、作者、国家、研究机构、发表期刊及基因进行计量学分析。结果近10年乳腺癌转移基因相关文献在2001～2007年间呈缓慢增长趋势,2008～2010年开始呈现明显上升趋势。发文量最大的国家、期刊、研究机构分别为中国、Breast Cancer Research andTreatment、天津医科大学。论文中涉及的乳腺癌转移相关基因共计567个,研究最多的基因为ERBB2。结论近10年间对乳腺癌转移相关基因的研究逐渐增多,中国在该研究领域也有一定的优势。采用多基因模型评估乳腺癌转移风险将是未来研究的趋势。Objective To comprehend the current study status of breast cancer metastatic genes in order to find the direction for further research.Methods We searched Embase,Medline/Pubmed and Biosis Preview database from January,2001 to December,2010.363 included papers on breast cancer prognostic genes were analyzed on publication year,authors,country,research institute,reported journal and gene with bibliometric approaches.Results The identified essays grew slowly during 2001-2007,showed obviously increasing trend from 2008 to 2010.The country,institution and journal that published most essays were China,Tianjin Medical University and Breast Cancer Research and Treatment.The identified essays covered 567 genes,of which ERBB gene wined the highest frequency.Conclusion The research essays on breast cancer prognostic genes are increasing.China in this field has some advantages.Using the multi-gene model to assess risk of breast cancer will be the trend of further research with the development of gene chip technology.

关 键 词：乳腺肿瘤 转移相关基因 计量学分析 

分 类 号：R737.9[医药卫生—肿瘤]