乳腺癌中细胞周期素D1的表达及其临床意义  

Expression of cyclin D1 in breast cancer

作　　者：杨澜[1] 王磊[1] 王旭芬[1] 

机构地区：[1]江苏省常州市第一人民医院乳腺外科,213003

出　　处：《中国医药》2012年第2期179-181,共3页China Medicine

摘　　要：目的探讨细胞周期素D1（cyclinD1）的表达及其与乳腺癌生成发展及预后之间的关系。方法采用免疫组化染色检测乳腺癌标本中cyelinD1的表达，与相关临床资料进行分析，实验结果用SAS6．12统计软件，使用“扩展的Mantel—Haenasel统计法”进行分析。结果年龄≤50岁与〉50岁cyelinD1阳性率分别为31例（81．6％）及27例（73．0％），原位癌、导管内癌伴部分浸润、浸润性癌患者cyclinD1的阳性率分别是66．7％，50．0％，81．O％。根据临床分期（TMN分期）0期、I期、Ⅱ期、Ⅲ期患者的cyelinD1阳性率分别为4例（66．7％），11例（61．1％），25例（80．6％），18例（90．0％）；有递增的趋势，且随着临床分期的增加细胞核染色cyclinD1阳性强度增加且差异有统计学意义。cyclinD1在乳腺癌中有高表达，且随乳腺癌的分期进展表达增高，有淋巴结转移、雌激素受体（＋）、P53（＋）的乳腺癌标本cyclinD1阳性表达率高。结论cyclinD1的表达与乳腺癌的形成发展及转移浸润有关，淋巴结转移多的乳腺癌cyclinD1表达高。cyclinD1与雌激素受体之间可能有独立作用，cyclinD1和P53可能相互作用共同参与了乳腺癌的形成。Objective To investigate the expression of cyclin D1 in the specimen of breast cancer and its correlation with pathologic staging, metastases of lymph nodes, estrogen receptor and anti-oneogene p53 in breast cancer. To reveal the relationship between the expression of eyelin D1 mad the generation, development, prognosis of breast cancer. Methods The expression of eyclin D1, estrogen receptor（ER） and P53 was detected through elivision plus immunohistochemical staining method in the breast cancer, and the results were analyzed with correlative clinical information. Results The expression of cyelin D1 was high in breast cancer. It intimately correlated with the metastases of lymph nodes and the expression of estrogen receptor and anti-oncogene p53. Conclusions The expression of cyclin D1 is associated with the generation and development of breast cancer. Separate effect may exist between eyclin D1 and estrogen receptor. Through possible interaction cyelin D1 and antincogene p53 participate together in the generation of breast cancer. Cyclin D1 may become a new predictor marker in the treatment of breast

关 键 词：乳腺肿瘤 细胞周期素D1 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]