肺癌患者血清胸苷激酶1检测的临床意义  

Significance of Serum Thymidinekinase Determination in Participants with Lung Carcinoma

作　　者：周黎东 彭春雷[2] 

机构地区：[1]苏州高新区镇湖医院,江苏苏州215161 [2]苏州大学附属第二医院免疫学实验室,江苏苏州215004

出　　处：《中国血液流变学杂志》2011年第4期658-660,共3页Chinese Journal of Hemorheology

摘　　要：目的探讨细胞质胸苷激酶I（TKI）检测对肺癌诊断的I临床价值。方法利用增强化学发光法（ECLA）检测65例肺癌患者血清TKl的含量，同时检测20例肺部良性疾病和20名健康志愿者血清中的TKl含量。结果肺癌患者TKI水平（3．71±2．86pmol／L）显著高于肺部良性疾病组（1．70±1．61pmol／L）和正常对照组（1．18±1．13pmol／L）（P〈0．01）；但肺部良性疾病组和正常对照组之间差异无统计学意义（JP〉0．05）。TKl的ROC曲线下面积为0.81，诊断肺癌的准确度中等偏高。结论TKl是一个有价值的肿瘤标志物，它的检测有助于肺癌的诊断。Objective To investigate the diagnostic value of serum thymidine kinase I（TK1） in lung carcinoma. Methods The levels of TKI in 65 patients with lung cancer,20 with benign lung disease and 20 normal controls were determined by enhanced chemiluminescence assay. Results The levels of TK1 in participants with lung carcinoma（3.71 ＋ 2.86pmol/L） were much higher than those in participants with benign disease（1.70 ＋ 1.61pmol/L） and normal controls（1.18 ＋ 1.13pmol/L）（P 〈 0.01）,but there was no significant difference between patients with benign disease and normal controls（P 〉 0.05）.The area under curve（AUC） of TIll was 0.81 by ROC analysis,and the diagnostic accuracy to lung carcinoma was moderate to high.Conclusion The detection of TK1 may have value in the diagnosis of lung carcinoma.

关 键 词：胸苷激酶 增强化学发光法 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]