注射用头孢西丁钠与注射用氯诺昔康配伍稳定性考察  

Compatible Stability of Cefoxitin Sodium and Lornoxicam for Injection

作　　者：陈富超[1] 方宝霞[1] 李鹏[1] 朱军[1] 杨盼鑫[2] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008 [2]湖北医药学院药学院

出　　处：《中国药师》2011年第12期1761-1763,共3页China Pharmacist

摘　　要：目的:考察注射用头孢西丁钠与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法:在(25±1)℃下,采用高效液相色谱法(HPLC)测定配伍液8 h内头孢西丁钠与氯诺昔康的含量变化,并观察和检测配伍液的外观、pH及不溶性微粒变化。结果:8 h内配伍液外观、pH、不溶性微粒及氯诺昔康的含量无明显变化,头孢西丁钠含量不断下降,8 h含量为95.5%。结论:室温条件下,注射用头孢西丁钠与注射用氯诺昔康在0.9%氯化钠注射液中8 h内保持稳定。Objective： To study the stability and compatibility of cefoxitin sodium for injection with lornoxicam for injection in 0. 9% sodium ehloride injection. Method： HPLC method was designed to study the content change after the combination of cefoxitin sodium for injection with lornoxieam in 0. 9% sodium chloride injection under the room temperature of （ 25 ± 1 ） ℃ within 8 hours. The appearance and particles in the solution were observed, and the pH value was determined. Result： No significant differences were found in the appearance, pH value, particles and content of lornoxicam of the mixed solution within 8 hours. The content of cefoxitin sodium siginificantly decreased in 8 hours with the last content of 95.5%. Conclusion： The mixture of cefoxitin sodium with lornoxicam in 0. 9% sodium chloride injection at ambient temperature was stable within 8 hours.

关 键 词：头孢西丁钠 氯诺昔康 高效液相色谱法 配伍 稳定性 

分 类 号：R942[医药卫生—药剂学]