事件相关电位P300、TCD检测对多发性脑梗死认知功能的评价  

Evaluation of Event-related Potential P300 and TCD Detection on Cognitive Function of Multiple Cerebral Infarction

作　　者：刘南平[1] 陈景云[1] 夏宪军[2] 沙彦妮[3] 林树敏[3] 潘宗[1] 孙海峰[3] 

机构地区：[1]宁夏医科大学总医院心脑血管病医院神经电生理科宁夏颅脑疾病重点实验室,银川750004 [2]宁夏医科大学,银川750004 [3]宁夏医科大学总医院神经电生理科宁夏颅脑疾病重点实验室,银川750004

出　　处：《宁夏医科大学学报》2012年第1期30-32,41,共4页Journal of Ningxia Medical University

基　　金：宁夏自然科学基金(NZ09121)

摘　　要：目的探讨多发性脑梗死后事件相关电位P300、经颅多普勒超声(TCD)检测对认知功能障碍的评判价值。方法采用P300检测病例组60例多发性脑梗死患者(经痴呆简易筛查量表BSSD测评再分为多发性脑梗死痴呆组38例,多发性脑梗死非痴呆组22例),30例正常对照组,对比分析痴呆、非痴呆组两组之间以及两组分别与正常对照组之间的P300结果;采用TCD检测病例组60例多发性脑梗死患者,分析颅内动脉各血流参数变化,并与P300潜伏期、波幅作对比分析。结果①P300检测多发性脑梗死患者的P300潜伏期比正常对照组明显延长,波幅明显降低(均P<0.05);痴呆、非痴呆组分别与正常对照组比较,P300潜伏期延长、波幅降低,均有统计学意义(P<0.05),但痴呆组与非痴呆组间P300潜伏期及波幅差异均无统计学意义(P>0.05);②TCD检测:总异常率为93.33%。符合血管狭窄36/60例(60.0%)、狭窄后慢性闭塞性改变12/60例(20.0%)、动脉硬化性血流改变32/60例(53.33%);流速正常12例。痴呆组和非痴呆组两组间TCD血流速度差异无统计学意义;TCD血流速度与P300潜伏期具有相关性。结论 P300对认知功能的评定优于痴呆简易筛查量表(BSSD);P300、TCD联合检测是评判认知功能的良好指标,为脑梗死后患者血管性痴呆的早期发生与发展提供了可靠依据。Objective To investigate the judgement value of the event-related potentials P300 and Transcranial Doppler ultrasound（TCD） on cognitive impairment of multiple cerebral infarction use.Methods 60 patients with multiple cerebral infarction（38 cases multi-infarct dementia and 22 cases with multiple infarct non-dementia） and 30 normal controls were detected by P300 method.Comparative analysis was performed among groups.Results 1.P300 testing： P300 latency in multi-infarct patients was significantly longer than that in normal control group and amplitude in multi-infarct patients was significantly reduced compared to that in normal control group;Difference of P300 latency and amplitude between dementia group and non-dementia group showed no significant difference;Compared P300 latency and amplitude of the control group with those of dementia group and non-dementia group respectively,significant difference were found.2.TCD detection： Total abnormal rate was 93.33% in which the stenosis 36/60 cases（60.0%）,the narrow chronic occlusive 12/60 cases（20.0%） and atherosclerotic changes in blood flow 32 / 60 cases（53.33%）.Conclusion P300 assessment is better than simple dementia screening scale（BSSD） in evaluation of cognitive function.Evaluation of cognitive function using P300 united with TCD is a good indicator for cerebral infarction in patients with early onset of dementia for assessment of the degree of vascular dementia.

关 键 词：多发性脑梗死 痴呆 认知功能 P300 TCD 

分 类 号：R743.3[医药卫生—神经病学与精神病学]