肿瘤标志物在84例孤立性小肺癌中表达的回顾性分析  

Tumor markers in 84 patients with solitary small lung cancer were retrospectively analyzed

作　　者：张亚兰[1] 王骋 胡佳杰[3] 

机构地区：[1]湖北中医药大学,湖北武汉430065 [2]马应龙药业集团股份有限公司,湖北武汉430064 [3]湖北中医药大学检验学院,湖北武汉430065

出　　处：《国际检验医学杂志》2012年第4期394-395,398,共3页International Journal of Laboratory Medicine

摘　　要：目的通过回顾性分析孤立性小肺癌患者的肿瘤标志物表达,探索肿瘤标志物在孤立性肺结节早期诊断中可能发挥的作用。方法对84例有完整肺部CT和经病理诊断确诊为孤立性小肺癌(直径小于或等于3cm)患者的肿瘤标志物表达的病历资料进行回顾性分析,以孤立性小肺癌的肿瘤直径大小和肺癌病理类型作为分类基础,以肿瘤标志物的阳性或阴性表达为观察指标进行统计学分析。结果不同直径大小的孤立性小肺癌之间肿瘤标志物的表达差异有统计学意义(P<0.05);在肺腺癌中CEA表达与其他类型肿瘤标志物的表达相比差异有统计学意义(P<0.05)。结论肿瘤标志物检测有助于早期孤立性肺结节的良恶性诊断;肿瘤标志物CEA在肺腺癌中存在高表达。Objective To explore potential role of tumor markers in early diagnosis of solit-ary pulmonary nodules by retrospec- tive analysis of tumor markers expression of patients with sol-itary small lung cancer. Methods Methods The medical records for expression of tumor markers were re- viewed by 84 patients with small lung cancer （diameter ≤ 3cm） confirmed by complete lung CT a-nd pathological diagnosis, through using the diameter of tumor size and pathology type as classif-ication basis, so as to statisti- cally analyze either positive or negative expression of tumor markers. Results There was statistical significance （P〈0.05） for tumor markers expression for solitary small lung cancer with different diameter; CEA expression in lung adenocarcinoma was sta- tistical significance （P〈0.05） when compared with other types of tumor markers expression. Conclusion Conclusion Detection of tumor markers in early solitary pulmonary nodule is helpful for differential diagnosis of benign and malignant; Tumor marker CEA is highly expressed in lung adenoearcinoma.

关 键 词：肺肿瘤 肿瘤标志物 硬币病变 肺 

分 类 号：R734.2[医药卫生—肿瘤]