白藜芦醇纳米载体的制备与表征  

Preparation and Characteration of Three Kinds of Resveratrol Loaded Nano-carriers

作　　者：赵吴君[1,2,3] 夏强[1,2,3] 

机构地区：[1]东南大学生物电子国家重点实验室,江苏南京210096 [2]东南大学苏州市生物医用材料与技术重点实验室,江苏苏州215123 [3]苏州纳康生物科技有限公司,江苏苏州215123

出　　处：《纳米科技》2012年第1期38-41,60,共5页

基　　金：科技部国际科技合作项目（2008DFB50060）

摘　　要：制备了负载1%白藜芦醇（Res）的三种脂质纳米载体,分别为固体脂质纳米粒（SLN）、纳米脂质载体（NLC）和纳米乳（NE）,通过进行离心、粒径、zeta电位、pH值、含量、包封率及对温度的稳定性等理化性质研究,结果表明,Res-SLN,粒径45±5nm,zeta电位-10.0±0.3mV,含量为9.57mg.mL-1,包封率为98.68%;Res-NLC,粒径185±3nm,zeta电位-10.8±0.5mV,含量为9.17mg.mL-1,包封率为99.36%;Res-NE,粒径7nm,zeta电位-4.8±0.4mV,含量为9.89mg.mL-1,包封率为97.97%。三种载体体系在4℃及25℃离心10000r/min,30min不分层。分别在室温、4℃、40℃下放置15d,Res-NLC表现出良好的稳定性。Three kinds of resveratrol loaded nano-carriers,such as SLN,NLC,and NE were prepared,respectively.The physicochemical characteristics of three nano-carrier were measured by centrifugation,particle size,zeta potential,pH,concentration,encapsulated efficiency,stability in different temperatures.The Results indicated that res-SLN,had particle size45±5nm,zeta potiential-10.0±0.3mV,and concentration 9.57mg·mL-1,and encapsulated efficiency 98.68%.Res-NLC,particle size 185±3nm,zeta potential-10.8±0.5mV,concentration 9.17mg·mL-1,and encapsulated efficiency 99.36%.Res-NE,particle size 7nm,zeta potential-4.8±0.4mV,concentration 9.89mg·mL-1 and encapsulated efficiency 97.97%.All of these three nano-carriers were stable after centrifugation（10000r/m,30min） at 4℃ and 25℃.The Res-NLC showed good stability for 15days at 4℃,room temperature,and 40℃.

关 键 词：白藜芦醇 SLN NLC NE 制备 表征 

分 类 号：TS201.2[轻工技术与工程—食品科学]