S100A4和血管内皮生长因子C、D在胃癌组织中的表达及其与淋巴结转移和预后的关系  

Correlation between expression of S100A4, vascular endothelial growth factor C and D with lymph node metastasis and prognosis in gastric carcinoma

作　　者：冯联忠[1] 郑雪勇[1] 李斌[1] 于亚威[1] 付斌[1] 周礼湘[1] 

机构地区：[1]浙江嘉兴学院附属第二医院肿瘤外科,314000

出　　处：《中华实验外科杂志》2012年第3期381-384,共4页Chinese Journal of Experimental Surgery

基　　金：嘉兴市科技局资助项目（2008AY2034-6）

摘　　要：目的观察人胃癌S100A4和血管内皮生长因子（VEGF）-C、VEGF-D的表达，探讨其与临床病理特征及预后的关系。方法应用免疫组织化学方法检测108例人胃癌及20例癌旁组织中S100A4和VEGF．C、VEGF-D的表达。分析S100A4和VEGF-C、VEGF-D表达与患者年龄、性别、肿瘤大小、病理类型、浸润深度、淋巴结转移和肿瘤TNM分期的关系，并作预后分析。结果S100A4和VEGF-C、VEGF-D在胃癌组织中的阳性率明显高于癌旁组织（P〈0．05）。S100A4的表达与肿瘤大小和淋巴结转移有关（P〈0．05），VEGF-C的表达与淋巴结转移和TNM分期有关（P〈0．05），VEGF．D的表达与淋巴结转移和TNM分期无明显相关（P〉0．05），肿瘤组织内S100A4和VEGF-C两者表达呈正相关（P〈0．05）。S100A4和VEGF-C、VEGF-D阳性胃癌患者5年生存率分别低于阴性患者，差异无统计学意义（P〉0．05）。结论S100A4和VEGF-C的表达与胃癌的淋巴结转移有关，S100A4可能参与VEGF．C淋巴管生成通路，在胃癌的淋巴结转移中发挥重要作用。Objective To research the expression of S100A4 and vascular endothelial growth fac- tor （VEGF） C and D in gastric carcinoma and there correlation with clinicopathological features and prognosis. Methods S100A4, VEGF-C and VEGF-D proteins were measured in 108 gastric carcinoma specimens and 20 specimens in adjacent carcinoma tissue by using immunohistochemistry. The correlations between the expression of S100A4, VEGF-C and VEGF-D with patients＇ age, gender, the tumor size, pathological differentiation, invasion depth, TNM stage and prognosis were evaluated. Results The expression levels of S100A4, VEGF-C and VEGF-D in gastric carcinoma were significantly higher than those in adja- cent carcinoma tissues （ P 〈 0. 05 ）. The expression of S100A4 was associated with the tumor size and lymph node metastasis （P 〈 0. 05 ）, and that of VEGF-C was associated with lymph node metastasis and clinical TNM stage （P 〈 0. 05 ）, but that of VEGF-D was not associated with lymph node metastasis and clinical TNM stage （P 〉 0. 05 ）. S100A4 was positively correlated with VEGF-C in carcinoma tissues （P 〈 0. 05）. Five-year survival rate of carcinoma patients with positive expression of S100A4, VEGF-C and VEGF-D was lower than that of negative cases, but there were no statistically significant differences （P 〉 0. 05）. Conclusion The expression of S100A4 and VEGF-C is associated wtih lymph node metastasis. The expression of VEGF-C is associated with the pathway of lymphangiagenesis and may play an important role in lymph node metastasis in gastric carcinoma.

关 键 词：胃肿瘤 SIOOA4基因 血管内皮生长因子 淋巴结转移 

分 类 号：R735.2[医药卫生—肿瘤]