甲磺酸丹诺沙星诱发中国仓鼠肺成纤维细胞(CHL)染色体畸变试验  

Study on CHL Cell Chromosome Aberration Induced by Danofloxacin Mesylate

作　　者：王树槐[1] 周明霞[1] 王国清 

机构地区：[1]中国兽药监察所,北京100081 [2]郑州兽药厂

出　　处：《中国兽药杂志》2000年第1期15-16,共2页Chinese Journal of Veterinary Drug

摘　　要：采用体外培养中国仓鼠肺成纤维细胞(CHL)对喹诺酮类新药甲磺酸丹诺沙星(Danofloxacinmesylate)的诱变性进行了检测,旨在对该药的遗传毒性作出评价,为安全用药提供数据。结果表明:加或不加代谢活化系统S9,甲磺酸丹诺沙星对CHL细胞未见致染色体畸变作用。The mutogenicity of the new fluoroquinolone drug,danofloxacin mesylate was studied in vitro in the cultures of the chinese humster lung fibroblast cell line CHL.The results showed that no cell chromosomal aberration emerged whether added on not the metabolic activator S 9 mix.

关 键 词：甲磺酸丹诺沙星 染色体畸变 CHL 遗传毒性 

分 类 号：S859.792[农业科学—临床兽医学]