前循环脑梗死患者可溶性白细胞分化抗原40配体水平变化及意义  

The significance and dynamic changes of expression of sCD40L in anterior circulation infarction patients

作　　者：谭峰[1] 刘晓林[1] 霍绮雯[1] 方美凤[1] 王学文[1] 李雁萍[1] 

机构地区：[1]广州中医药大学附属佛山中医院神经内科,广东佛山528000

出　　处：《中国现代医学杂志》2011年第30期3726-3729,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81072947);国家重点基础研究发展计划(No:2003CB517102);广东省科技厅基金资助项目(No:20100309)

摘　　要：目的观察急性前循环脑梗死(AACI)患者发病后不同时间、不同梗死体积、不同神经功能缺损外周血中可溶性白细胞分化抗原40配体(sCD40L)水平,并探讨其动态变化的临床意义。方法选择发病72 h内的AACI患者38例,用酶联免疫分析(ELISA)法检测其入院后第1、7天血清sCD40L水平,同时观察不同梗死体积与神经功能缺损程度AACI患者上述指标的相关性,并与健康人组33例测定值作对照。结果 ACI患者入院第1天血清sCD40L水平(8.0061±5.00198)ng/mL明显高于健康人组(1.5353±1.0005)ng/mL(P<0.01),第7天患者sCD40水平(6.4123±3.3168)ng/mL虽有下降,但仍高于健康人组(P<0.05);大梗死组患者sCD40水平(10.0960±2.2117)ng/mL明显高于中小梗死组(7.6143±5.2981)ng/mL(P<0.01);脑梗死体积与MBI呈负相关(γ=-0.582,P<0.01)。结论 sCD40L是AACI脑缺血损伤的重要炎性致病因素之一,检测sCD40L水平有益于AACI患者的病情评估和预后分析。[Objective]To observe the expression of sCD40L in different time and different cerebral infarction volume（CIV） in acute anterior circulation infarction（AACI） patients with different neurologic impairment,and study its significance and contribution of dynamic changes in the development of AACI.[Methods]The expression of sCD40L in 38 cases of ACI patients who were admitted within 72 hours were respectively detected by ELISA at 1-day and 7-day after admission,and the correlation between different CIV,different degree of neurologic impairment and the expression of sCD40L were analyzed The expression of sCD40L in 33 cases of healthy people with the age and sex matched were selected as the control.[Results]The expression of sCD40L in AACI patients on the 1 -day （8.0061±5.00198） ng/mL after admission was significandy higher compared to healthy people（1.5353±1.0005） ng/mL （P〈0.05）,but markedly decreased on 7-day（6.4123±3.3168） ng/ml which was still higher than in healthy people（P〈0.05）.The expression of sCD40L in larger CIV group（10.0960±2.2117） ng/mL was higher than those in middle small CIV groups（7.6143±5.2981） ng/mL（P〈0.01）.There was negative correlation between ICV and MBI（γ=- 0.582,P〈0.01）.[Conclusion]The sCD40L is one of the crucial inflammatory pathogenetic factors for AACI.Clinical detection of expression of sCD40L could benefit to the assessment of severity of patient＇s condition and the prognosis judgment of AACI patients

关 键 词：急性前循环脑梗死 可溶性白细胞分化抗原40配体 梗死体积 

分 类 号：R743[医药卫生—神经病学与精神病学]