美沙酮维持治疗对男性患者工作记忆的影响  

Effects of methadone maintenance treatment on working memory in male heroin dependent patients

作　　者：尹良爽[1] 李泽爱[2] 庞良俊[2] 朱春燕[1] 王士梅[3] 张丽 唐炜超[2] 戴兢[1] 

机构地区：[1]安徽医科大学医学心理学系,合肥230032 [2]安徽省精神卫生防治中心 [3]淮南市精神病医院药物维持治疗门诊

出　　处：《中华医学杂志》2012年第7期464-467,共4页National Medical Journal of China

摘　　要：目的 探讨美沙酮维持治疗（MMT）男性海洛因依赖患者和健康对照（HC）组之间工作记忆的差异.方法 对42例2010年5至10月在淮南市精神病医院门诊就诊的MMT患者及2010年5至12月与其人口学资料相匹配的31名健康志愿者进行空间、语音及面孔工作记忆测试,比较两组正确率及反应时间的差异.结果 在排除焦虑、抑郁情绪及尿吗啡测试阳性情况下,MMT组在语音工作记忆,正确率低于HC组（分别为83％±9％,89％±10％）,差异有统计学意义[t（71）=-2.631,P=0.010]；而在空间工作记忆,面孔工作记忆,2组正确率差异无统计学意义（P＞0.05）；2组在进行三项工作记忆测试时,反应时差异均无统计学意义（均P ＞0.05）；研究同时还发现,MMT剂量高低组间比较及MMT时间长短组间比较,均未发现存在工作记忆及执行功能的差异.结论 MMT患者工作记忆损伤并不均衡,可能与患者脑区损伤不同有关.MMT时间和剂量对患者工作记忆及执行功能并无显著影响.Objective To explore the differences of working memory task performance between male patients with heroin dependence in methadone maintenance treatment （MMT） and healthy controls （HC）.Methods A total of 42 heroin-dependent patients at Huainan City Psychiatric Hospital from May 2011 to October 2011 were compared with 31 gender- and age-matched HCs on such working memory tests as visualspace,visual-verbal and visual-face.Then the accurate rate and reaction time of the above tasks were between two groups.Results The participants with anxiety or depression were excluded.All MMT subjects were required to have negative urine toxicology screening tests.The accurate rate of verbal working memory of the patients was worse than that of HCs （83% ±9% vs 89% ± 10% ）.And the difference was significant between two groups （ t （71） =- 2.631,P =0.010）.The accurate rate of visual-object and visual-spatial working memory showed no significant differences between two groups （ P 〉 0.05 ）.The differences in reaction time on these tasks showed no statistical significance between two groups （ P 〉 0.05 ）.In addition,the dose of methadone and the duration of MMT revealed no significant effects on the performance of working memory and executive functions.Conclusion The disproportion impairment of patients on space,verbal and face working memory is probably due to the differential heroin-mediated injuries of encephalic regions.Methadone has no effect on working memory and executive functions in the patients with a history of heroin use during maintenance treatment intervention.

关 键 词：海洛因依赖 美沙酮 记忆 

分 类 号：R749.64[医药卫生—神经病学与精神病学]