食管支架治疗中晚期食管癌预后影响因素的Cox回归分析  

Cox regression analysis of prognostic factors on advanced esophageal carcinoma after esophageal stenting

作　　者：黄迁祥[1] 顾俊鹏[1] 纪卫政[1] 迪理木拉提.巴吾冬 任伟新[1] 杨树法[2] 周东海[3] 

机构地区：[1]新疆医科大学第一附属医院介入放射科,新疆乌鲁木齐830054 [2]新疆医科大学附属肿瘤医院介入科,新疆乌鲁木齐830011 [3]克拉玛依市中心医院放射介入科,新疆克拉玛依834000

出　　处：《中国介入影像与治疗学》2012年第3期186-190,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的探讨食管支架置入术后影响中晚期食管癌患者生存期的因素。方法回顾性分析103例接受金属覆膜食管支架置入术的中晚期食管癌患者的临床资料,选择性别、年龄、食管瘘、肿瘤长度、浸润深度、分化程度、临床分期、组织类型、术后化疗和术后放疗10个可能对食管支架置入术预后产生影响的因素,应用Cox回归模型分析其对预后的影响。结果单因素Cox回归分析显示食管瘘、肿瘤长度、浸润深度、分化程度及临床分期均对预后有显著影响(P均<0.05)。进一步行Cox模型多因素分析,显示肿瘤分化程度及临床分期为影响预后的独立因素(P均<0.05)。结论影响食管支架置入术后中晚期食管癌患者生存期的主要因素是肿瘤分化程度及临床分期;支架置入术后进一步放疗和化疗不能延长生存期。Objective To assess the impact factors on survival time of patients with advanced esophageal cancer after stent implantation.Methods Data of 103 patients with advanced esophageal cancer who received covered endoscophageal stent implantation were retrospectively analyzed.Cox regression analysis was performed to examine the following factors on survival time,such as age,gender,fistula,tumor length,tumor invasion depth,pathologic type,grade of cell differentiation,clinical tumor stage,postoperative chemotherapy and radiotherapy.Results Single factor Cox regression analysis showed that fistula,tumor length,tumor invasion depth,grade of cell differentiation and clinical tumor stage had significant influence on prognosis（all P0.05）.Multiple Cox regression analysis showed that only grade of cell differentiation and clinical tumor stage were independent influence factors on prognosis（both P0.05）.Conclusion Grade of cell differentiation and clinical tumor stage are the major impact factors of prognosis that affect the survival of patients with unresectable esophageal carcinoma after stenting.There is no benefit for survivals treated with radiotherapy and/or chemotherapy after esophageal stenting.

关 键 词：食管肿瘤 支架 预后 回归分析 

分 类 号：R735.1[医药卫生—肿瘤]