吸液缓溶性壬苯醇醚膜的急性毒性和致突变性研究  

Study on the acute toxicity and mutagenicity of the imbibition slow solution nonoxynol-9 membrane

作　　者：李荣秀 李国正 胡殿珍 将东升[3] 常凤启[3] 胡振华 

机构地区：[1]河北省计划生育科学技术研究院,石家庄050071 [2]河北省丰宁县计划生育技术服务站,河北丰宁068350 [3]河北省疾病预防控制中心,石家庄050021

出　　处：《生殖医学杂志》2012年第1期55-58,共4页Journal of Reproductive Medicine

摘　　要：目的研究吸液缓溶性壬苯醇醚膜的急性毒性和致突变性,为评价安全性提供毒理学依据。方法使用昆明种清洁级小鼠进行急性经口毒性实验,小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形实验。结果对小鼠的急性经口毒性试验,LD_(50)>5,000mg/kg体重,属于实际无毒物。小鼠骨髓嗜多染红细胞微核和小鼠精子畸形率实验结果均为阴性,无致微核作用和无致精子畸形作用。结论吸液缓溶性壬苯醇醚膜无急性毒性作用,对体细胞和生殖细胞无致突变性。Objective： To study the acute toxicity and mutagenicity of the imbibitlon slow solution nonoxynol-u （NP-9） membrane for evaluating its security. Methods： Toxicological properties of the membranes were evaluated by acute toxicity test, the micro- nucleus tests with bone marrow polychromatic erythrocyte and sperm abnormality tests in Kunming mice. Results： LD50 of the imbibition slow solution NP-9 membranes in Kunming mice was more than 5000 mg/kg, bw, and no toxic effects were observed. The results of micronucleus test and sperm abnormality test were negative. Conclusions： The imbibition slow solution NP-9 membrane had no acute toxicity and mutagenic action on somatic cell and germ cell.

关 键 词：急性毒性 致突变性 吸液缓溶 壬苯醇醚-9 

分 类 号：R[医药卫生]