胃癌组织中花生四烯酸水平与肿瘤分化程度及性别关系的初步观察  

Association of arachidonic acid level in gastric cancer tissue with gender and tumor differentiation

作　　者：宋虎[1] 彭俊生[1] 李初俊 向军[1] 刘中辉[1] 王华摄[1] 杜艳平 

机构地区：[1]中山大学附属第六医院食管胃肠外科广州,510655 [2]消化内镜中心,510655 [3]临床营养中心,510655

出　　处：《中华临床营养杂志》2012年第1期22-25,共4页Chinese Journal of Clinical Nutrition

摘　　要：目的探讨胃癌组织中花生四烯酸（AA）含量及其与肿瘤分化程度及性别的关系。方法采用气相色谱联合质谱分析技术对从胃癌组织中提取的花生四烯酸进行定量分析并与周围配对的正常黏膜进行对照。分析AA水平与胃癌分化程度及性别的关系。结果胃癌组织中AA含量（0．190％±0．255％）显著少于配对正常胃黏膜组织（0．274％±0．254％，n=30，P：0．011）。不同TNM分期胃癌组织和配对正常胃黏膜组织比较或者不同TNM分期胃癌组织之间比较AA含量的差异无统计学意义（P均〉0．05）。高一中分化腺癌（0．173％-4-0．244％）和低分化腺癌组织中AA含量（0．195％±0．264％）较配对正常黏膜组织（0．334％±0．170％和0．256％±0．275％）显著减少（P=0．018和P=0．043）；高冲分化和低分化腺癌组织中AA水平的差异无统计学意义（P=0．895）。男性患者胃癌组织中AA含量（0．137％±0．209％）较配对正常胃黏膜组织（0．275％±0．238％）显著减少（P=0．010）；女性患者胃癌组织中AA含量和配对正常胃黏膜组织中AA含量比较（P=0．477）或男女患者胃癌组织中AA含量比较（P=0．139）差异均无统计学意义。结论AA含量在胃癌组织中明显降低，其可能与肿瘤分化程度和患者性别有关，男性胃癌患者胃癌组织中AA消耗更为明显。Objective To explore the association of arachidonic acid （AA） level in gastric cancer （GC） tissue with tumor differentiation and patients＇ gender. Methods The contents of AA in GC tissue and adjacent matched normal mucosa were measured using gas chromatography/mass spectrometry. The relationships of AA with GC differentiation and patients＇ gender were analyzed. Results The level of AA significantly decreased in GC tis sue （0. 190% ＋ 0. 255 %） compared with normal tissue （0. 274% ＋ 0. 254% , n = 30, P = 0. O11 ） , while the level of AA had no significant difference in the tissues of matched normal mucosa and different TNM stages or among dif ferent TNM stages （ all P 〉 0. 05 ）. The AA levels in well and moderately differentiated adenocarcinoma （0. 173% ＋ 0. 244% ） and in poorly differentiated adenocareinoma （0. 195% ＋ 0. 264%） were significantly decreased when com pared with those in the paired normal mucosa （0. 334%＋ 0. 170%, P = 0. 018; 0. 256% ＋ 0. 275%, P = 0. 043, re spectively）, while no significant difference was observed between the different differentiated grades （ P = 0. 895 ）. The level of AA significantly decreased in male patients （0. 137% ＋0. 209% ） as compared with paired normal mueo sa （0. 275% ＋ 0. 238%, P = 0. 010）, while no positive correlation was observed in female patients as compared with normal group （P = 0. 477） or in the comparison between male and female groups （P = 0. 139）. Conclusions The AA level remarkably decreases in GC tissue, which may be associated with differentiated grades and patients＇gender. In addition, more AA is utilized in male GC patients than female patients.

关 键 词：胃癌 花生四烯酸 组织 

分 类 号：R735.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]