姜精油对急性血瘀模型大鼠血液流变学的影响  

Influences of Ginger Essential Oil on Hemorheology in Rats with Acute Blood Stasis

作　　者：黄静[1] 蒋伟哲[1] 谭建宁[2] 黄兴振[1] 巫玲玲[1] 施晓霞[1] 

机构地区：[1]广西医科大学药学院,南宁530021 [2]广西中医学院药学院,南宁530001

出　　处：《中国药房》2012年第11期969-971,共3页China Pharmacy

基　　金：广西自然科学基金项目(2010GXNSFA013201)

摘　　要：目的:研究姜精油对急性血瘀模型大鼠血液流变学的影响。方法:以静脉注射高分子右旋糖酐复制急性血瘀大鼠模型。实验分为6组,即正常对照(0.05%吐温80)、模型(0.05%吐温80)、复方丹参片(1500mg·kg-1)和姜精油高、中、低剂量(80、20、5mg·kg-1)组。检测大鼠血液流变学各项指标。结果:低、中、高剂量姜精油可显著降低血瘀大鼠的全血低、中、高切黏度,血浆黏度,全血还原黏度,红细胞压积值和红细胞聚集指数,并能升高红细胞变形指数。结论:姜精油可明显改善急性血瘀模型大鼠的血液流变性,能改善血液的高黏状态,防止血液黏度增加。OBJECTIVE： To observe the effects of ginger essential oil on hemorheology of rats with acute blood stasis. METHODS： The model of acute blood stasis was established with high-molecular weight dextran intravenously in rats. Rats were divided into 6 groups, i.e. normal control group （0.05 % tween-80）, model group （0.05 % tween-80）, Compound danshen tablet group （ 1 500 mg·kg^-1） and Ginger essential oil high-dose, medium-dose and low-dose groups （80,20,5 mg·kg^-1）. Hemorheological parameters of rats were determined. RESULTS： Ginger high-dose, medium-dose and low-dose groups could markedly decrease the whole blood viscosity with low, middle and high shear rate, plasma viscosity, blood reduce viscosity, hematocrit and erythrocyte con- glomeration index; It could also rise erythrocyte deformation index. CONCLUSION： Ginger essential oil can significantly ameliorate the hemorheology and inhibit platelet aggregation in acute blood-stasis model rats, and prevent the increase of blood viscosity.

关 键 词：姜精油 大鼠血瘀模型 血液流变学 高分子右旋糖酐 

分 类 号：R285.6[医药卫生—中药学] R97[医药卫生—中医学]