正交试验优选复方鱼腥草颗粒中连翘挥发油β-环糊精包合工艺  

Optimization of the β-cyclodextrin Inclusion Technology for Essential Oil of Forsythia suspensa in Compound Yuxingcao Granules by Orthogonal Test

作　　者：宋宁宁 许扬彪 

机构地区：[1]广西壮族自治区食品药品检验所,南宁530021

出　　处：《中国药房》2012年第11期997-998,共2页China Pharmacy

摘　　要：目的:研究β-环糊精(β-CD)对复方鱼腥草颗粒中连翘挥发油的包合工艺。方法:以β-CD与挥发油的配比、包合时间、包合温度、加水量为考察因素,以挥发油收得率和包合率的综合评分为评价指标,采用正交试验优选工艺。结果:优选的工艺为挥发油与β-CD的比为10mL∶80g、包合时间为4h、包合温度为60℃、加水量为β-CD的8倍。结论:所选工艺简单、可行,可有效地防止挥发油有效成分的散失。OBJECTIVE： To study the inclusion technology for the essential oil of Forsythia suspensa in Compound yuxingcao granules using β-cyclodextrin. METHODS： The inclusion technology was optimized with ratio of β-CD to oil, inclusion time, inclusion temperature and ratio of water to β-CD as factors using the yield of essential oil and clathration percentage as index. RESULTS： The optimal condition： ratio of essential oil to β-CD was 10 mL：80 g; the process lasted for 4 hours at 60 ℃; 8 times of water respect to β-cyclodextrin was added. CONCLUSION： The technology is proved to be simple, feasible and effective to the dissipation of avoid active gradients from essential oil.

关 键 词：复方鱼腥草颗粒 连翘挥发油 Β-环糊精 正交试验 包合工艺 

分 类 号：R284.2[医药卫生—中药学] R283.62[医药卫生—中医学]