阿尔茨海默病患者甲状腺激素与皮质醇测定的临床意义及其相关性  

Clinical significance of determination of serum thyroid hormones and cortisol in patients with alzheimer disease and their correlations

作　　者：王丽君[1] 吴丽丽[1] 程磊[1] 胡皖玲[1] 于小妹[1] 

机构地区：[1]浙江医院,杭州310013

出　　处：《中国卫生检验杂志》2012年第2期292-294,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨阿尔茨海默病(AD)患者血清甲状腺激素与皮质醇(CORT)水平的变化以及它们的相关性。方法:采用简易精神状态量表(MMSE)对77例AD患者和100例同龄健康人进行评分,对77例AD患者和100例健康对照组进行甲状腺激素(TT3、FT3、TT4、FT4、TSH、TU)和皮质醇(CORT)的测定,并进行组间对比研究和相关性研究。结果:AD患者TT3、FT3水平明显低于健康对照组(P<0.001,P<0.001);TU、皮质醇水平明显高于健康对照组(P<0.001,P<0.01),差异有显著性。AD患者TT4、FT4水平低于健康对照组,TSH水平高于健康对照组,差别无统计学意义(P均>0.05)。AD患者血清皮质醇水平与MMSE得分呈显著负相关,与甲状腺激素水平无显著相关性;AD患者TT3水平与FT3、TT4水平呈显著正相关,TT3水平与TU水平呈显著负相关,FT3水平与TT4水平呈显著正相关,FT3水平与TU水平呈显著负相关,TT4水平与FT4水平呈显著正相关。结论:甲状腺功能异常可能与AD的发病有关,血清皮质醇水平的增高可能与AD病程的进展有关。Objective ：To discuss the content changes of serum thyroid hormones and cortisol （CORT） in patients with Alzhei- mer disease（AD） and their correlations. Methods： The serum concentration of thyroid hormones （TT3, FT3, Tr4, FF4, TSH, TU） and cortisol（CORT） in 77 patients with AD and 100 normal controls was measured respectively. After grouping by degree of dementia with Clinical Dementia Rating Scale, the results were compared between each two groups and carried on the relevant re- search. The mental state was scored using Mini -mental state examination（MMSE）. Results： The serum TI3 and FT3 levels in AD patients were significantly lower than those in normal controls （P 〈 0. 001, P 〈 0.001 ）, and the serum TU and cortisol levels were significantly higher than those in normal controls （P 〈 0.001 ,P 〈 0.01 ）, all the difference was extremely significant. The serum TT4 and FT4 levels in AD patients were lower than those in normal controls, and the serum TSH was higher than that of nor- real controls, and the serum TSH was higher than that of normal e0ntrols, but all the difference was no statistical significance （ all the P 〉 0.05 ） and the serum TSH was higher than that of normal controls, but all the difference was no statistical significance （ all the P 〉 0.05 ）. Significant negative correlation existed between serum cortisol level and MMSE scores. No correlation existed be- tween serum eortisol level and serum thyroid hormones level. Significant positive correlation existed between serum FT3 level and serum rI＇Y4 level, while significant negative correlation existed between serum FT3 level and serum TU level. And significant posi- tive correlation existed between serum TT4 level and serum FT4 level. Conclusion： Abnormal serum thyroid hormones level may be related with AD. And the serum cortisol level is possibly related with the AD＇s progress.

关 键 词：阿尔茨海默病 甲状腺激素类 皮质醇 

分 类 号：R749.16[医药卫生—神经病学与精神病学]