甲胎蛋白、甲胎蛋白异质体、铁蛋白和肿瘤相关因子联合检测在原发性肝癌诊断中的价值  

Diagnostic value of AFP,AFP-L3,Fer and TSGF in primary liver cancer

作　　者：许成新[1] 褚邦勇[1] 徐玖飞[1] 林黎[1] 

机构地区：[1]温州医学院附属恩泽医疗中心集团浙江省台州医院,浙江台州317000

出　　处：《中国卫生检验杂志》2012年第2期308-309,311,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨甲胎蛋白(AFP)、甲胎蛋白异质体(AFP-L3)、铁蛋白(Fer)和肿瘤相关因子(TSGF)联合检测对原发性肝癌(PHC)早期诊断的临床价值。方法:对80例原发性肝癌组、60例良性肝病组和60例健康人群的AFP、AFP-L3、Fer和TSGF分别采用化学发光微粒子免疫分析法、亲和吸附法、微粒子酶促化学发光法以及酶联免疫吸附法检测其含量。结果:AFP、AFP-L3、Fer和TSGF单个肿癌标志物诊断原发性肝癌的敏感性分别为87.5%、85.0%、90.9%、88.8%,特异性分别为94.8%、97.0%、86.5%、85.3%;四种肿瘤标志物联合检测在PHC诊断中的敏感性和特异性分别为98.9%和99.8%,联合检测的敏感性与单项检测有统计学意义(P<0.01)。结论:应用AFP、AFP-L3、Fer和TSGF联合检测可大大提高原发性肝癌的检出率。Objective： To explore the clinical diagnostic value of AFP, AFP - L3, Fer and TSGF in primary liver cancer （PHC）. Methods： Two hundred cases were divided into PHC group（ n = 80） and Benign liver disease group（ n = 60）and normal control group（ n = 60）, corpuscule chemiluminescence immunoassay method, affinity absorption, corpuscule enzymic reaction chemiluminescence method and Enzyme - linked immunosorbent assay were used to detect serum AFP, AFP - L3, Fer and TSGF of these three groups. Results： In single marker diagnosis, the sensibilities of AFP, AFP - L3, Fer and TSGF for PHC were 87.5%, 85.0% ,90.9% and 88.8% respectively, while the specificities of them were 94.8%, 97.0%, 86.5%, 85.3%. The sensibility and specificity of combined diagnosis of these four tumormarkers were 98.9% and 99.8% respectively. There were significant differences between single diagnosis and combined diagnosis in the sensibility（P 〈 O. O1 ）. Conclusion： Combined di- agnosis of AFP, AFP - L3, Fer and TSGF can remarkably improve the detection rate of primary hepatocellular carcinoma.

关 键 词：甲胎蛋白 甲胎蛋白异质体 铁蛋白 肿瘤相关因子 原发性肝癌 肿瘤相关物质 

分 类 号：R730.43[医药卫生—肿瘤]