放疗对兔下颌骨延长的影响研究  

Bone lengthening in the irradiated rabbit mandible

作　　者：麻益可[1] 沈国芳[2] 王丽珍[2] 

机构地区：[1]温州医学院附属第一医院口腔科,325000 [2]上海交通大学医学院附属第九人民医院口腔颌面外科

出　　处：《浙江医学》2012年第3期179-182,共4页Zhejiang Medical Journal

基　　金：上海市重点学科（优势学科）建设项目（Y0203）

摘　　要：目的 本研究旨在初步了解放射后兔下颌骨是否进行骨延长术,以期为临床应用提供实验±据.方法 将实验兔随机分为两组：50Gy 组（6 只）和对照组（4 只）.前者用经50Gy 放射后1个月进行骨延长术,间歇8d 后,以0.4mm/ 次、2次/d 的速度进行牵引,固定期6 周.6 周后处死实验兔,对下颌骨的新生骨进行观察和组间比较.结果 标本和X 线均显示两组成骨均良好,与周围骨质无明显的界限,但是HE 切片显示：50Gy 组较对照组骨小梁稀疏、细小,并可见成片状致密纤维结缔组织.50Gy 组和对照组的骨小梁面积比分别为0.445±0.054 和0.588±0.081,两组的差异有统计学意义（P＜0.05）.结论 兔下颌骨放射后1 个月时骨延长术可以形成新生骨,但固定期6 周内新生骨的形成受到轻微抑制.Objective To investigate the influence of preoperative irradiation on the bone lengthening in rabbit mandible. Methods Ten rabbits were randomly divided into 2 groups： radiation group （n=6） in which the rabbits received 50Gy radiation, and control group （n=4）. One month after irradiation, the distractors were used. After a latency of 8 days, distraction was activated at a rate of 0.4ram, twice a day. The rabbits were sacrificed 6 weeks after consotidation. The new bone regeneration was evaluat- ed by macrography, radiography and histology. Results The specimens and radiographs showed good bone formation. The histology confirmed the bony structure regeneration. The bone trabeculas area ratio of the 50Gy group was 0.445±0.054 and the control group was 0.588± 0.081 （P 〈 0.05）. Conclusion The preoperative radiation impairs optimal bone regeneration of bone lengthening in the rabbit mandible.

关 键 词：骨延长 牵引成骨术 兔 下颌骨 放射治疗 

分 类 号：R782.23[医药卫生—口腔医学]