新型哌啶类杂环化合物的设计、合成与表征  

Design,Synthesis and Characterization of New Piperidine Heterocyclic Compounds

作　　者：覃宇[1] 张宝徽[1,2] 

机构地区：[1]武汉职业技术学院生物工程学院,武汉430074 [2]湖北中医药大学药学院

出　　处：《数理医药学杂志》2012年第1期89-92,共4页Journal of Mathematical Medicine

摘　　要：利用计算机辅助药物设计技术设计了6个可能具有阿片κ受体亚型或次亚型作用的哌啶类衍生物。其中化合物4-(噻唑-2-基)哌啶和3-(3-丙基-1,2,4-恶二唑-5-基)哌啶已被成功合成,总收率分别为26.2%和60%。对中间体和目标产物进行了LC-MS、1H NMR和元素分析表征。Six k-opioid receptor subtypes, which may have the role of sub-subtypes piperidine derivatives, were designed by the computer-aided drug design software. Among them, compound 4-（thiazol-2-yl） piperidine and 3-（3-propyl-1,2,4-oxadiazol-5-yl）piperidine were successfully synthesized, the total yield is 26. 2% and 60% respectively. The intermediates and target products were characterized by LC-MS, 1H NMR and elemental analysis.

关 键 词：阿片受体 哌啶 杂环 拮抗剂 

分 类 号：TQ340.79[化学工程—化纤工业]