非小细胞肺癌患者手术前后血清CA21-1的表达水平变化及意义  

Study on serum CA21-1 level alteration in non-small cell lung cancer before and after operation

作　　者：张辉[1,2] 沈振亚[1] 胡正群[2] 张淼[2] 刘冬[2] 潘雪峰[2] 

机构地区：[1]苏州大学第一附属医院心血管外科,苏州215006 [2]东南大学附属徐州医院胸外科

出　　处：《现代预防医学》2012年第5期1279-1280,1283,共3页Modern Preventive Medicine

摘　　要：目的研究非小细胞肺癌患者手术前后血清细胞角蛋白19片段（cytokeratin 19 fragment,CA21-1）表达水平变化及意义。方法 2006年1月~2010年12月期间,收集非小细胞癌行外科手术切除治疗患者276例,采用ELISA法检测患者血清CEA（癌胚抗原,Carcino-embryonic antigen）、NSE（神经特异性烯醇化酶,Neuron-specific enolase）、SCC-Ag（鳞癌相关性抗原,Squamous cell carcinoma antigen）和CYFRA21-1水平,分析手术前后此四项血清肿瘤指标的表达水平变化,对各指标均数的变化采用组间t检验,计数资料采用组间χ2检验,检验水平P=0.05。结果 276例非小细胞癌行外科手术切除治疗患者手术前后的CA21-1水平进行了比较,结果显示非小细胞肺癌患者手术前血清CA21-1水平（6.5±1.6）μg/L,手术后（2.2±1.9）μg/L,二者相比较差异具有统计学意义（t=8.125,P﹤0.05）。手术前血清CA21-1阳性率51.8%（141/276）,手术后17.8%（49/276）,二者相比较差异具有统计学意义（χ2=18.325,P=0.000）。结论手术前后检测血清CA21-1水平有助于评估手术疗效,指导进一步的综合治疗,值得进一步临床推广应用。OBJECTIVE To investigate the effect of operation on tumor index CA21-1 level in non-small cell lung cancer patients.METHODS From January 2006 to December 2010,276 cases of non-small cell lung cancer accepted operation were recruited.The tumor indexes including CEA,NSE,SCC and CYFRA21-1 before and after operation were detected by ELISA,and then analyzed by paired t test in SPSS 17.0.RESULTS After surgery operation,CA21-1 level（6.5±1.6μg/L vs.2.2±1.9μg/L,t = 8.125,P﹤0.05）was obviously decreased as compared with that before the operation.The CA21-1 positive rate（17.8%）in non-small cell lung cancer patients was lower than that before operation（51.8%）,P﹤0.05.CONCLUSION The screening of tumor indexes such as CA21-1 could be beneficial to the evaluation of surgery operation performance,which deserves further study.

关 键 词：非小细胞性肺癌 血清细胞角蛋白19片段 神经特异性烯醇化酶 癌胚抗原 

分 类 号：R734.2[医药卫生—肿瘤]