依达拉奉对血管性痴呆患者认知功能的影响  

Influence of Edaravone on Cognitive Function in Patients With Vascular Dementia

作　　者：周广安[1] 杨申[1] 宁方波[1] 

机构地区：[1]泰安市中心医院神经内科,山东271000

出　　处：《社区医学杂志》2012年第4期31-32,共2页Journal Of Community Medicine

摘　　要：目的观察依达拉奉对轻中度血管性痴呆患者认知功能的影响,并探讨其可能的作用机制。方法 80例轻中度血管性痴呆患者随机分为依达拉奉治疗组和吡拉西坦对照组,其中每组各40例,疗程为2周,临床效果评价采用简易精神状态检查(MMSE)、画钟试验(CDT)和蒙特利尔认知评估量表(MoCA)量表)进行评估。结果依达拉奉治疗后MMSE、CDT、MoCA分值较治疗前均有显著性差异(P<0.05);吡拉西坦对照组MMSE、CDT、MoCA分值较治疗前无明显变化(P>0.05)。结论依达拉奉通过清除自由基,抗氧化损伤,改善血管性痴呆患者的认知功能。Objective To detect the influence of Edaravone Injection on cognitive function in patients with vascular dementia（VD）,and to discuss its probable mechanism.Methods 80 patients with mild to moderate VD were randomly divided into two groups： Edaravone group（40 cases treated with Edaravone Injection） and control group（40 cases treated with Piracetam Injection）.After a 2-week treatment,scores of MMSE,CDT and MoCA were used to evaluate the clinical efficacy.Results After the treatment with Edaravone Injection,the scores of MMSE,CDT and MoCA were found to be significantly higher.The scores has no significant difference in the controls（P0.05）.Conclusions Edaravone Injection can improve the cognitive function in VD patients by protecting the body against free radicals and oxidative damage.

关 键 词：依达拉奉 血管性痴呆 认知功能 吡拉西坦 

分 类 号：R743.9[医药卫生—神经病学与精神病学]