维生素A缺乏影响肠道屏障功能的研究进展  

Progress of vitamin A deficiency affecting on intestinal epithelial barrier function

作　　者：刘霞[1] 李廷玉[1] 陈洁[1] 

机构地区：[1]f重庆医科大学附属儿童医院儿童营养研究中心,儿童发育疾病研究省部共建教育部重点实验室,儿科学重点实验室,重庆市儿童发育重大疾病诊治与预防国际科技合作基地,重庆400014

出　　处：《生命科学》2012年第1期32-36,共5页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81070286);教育部留学回国人员科研启动基金(教外司留[2009]1001)

摘　　要：维生素A(vitamin A,VA)在维持肠道黏膜上皮屏障功能的完整性、调节黏膜免疫反应以及抗感染中起到重要的作用。肠道相关树突状细胞(dendritic cells,DCs)可表达合成视黄酸(retinoic acid,RA)所必需的酶(retinal dehydrogenase,RALDH),合成RA。RA通过诱导T、B细胞产生整合素α4β7、CCR9,使其归巢到肠道,并提高肠道黏膜sIgA的水平。RA可增强天然CD4+T细胞分化为Foxp3+Treg细胞,抑制Th17细胞的生成。当机体VA缺乏时可降低肠道屏障功能,下调肠道黏膜免疫反应,增加肠道感染性疾病的易感性,容易导致腹泻。针对维生素A在肠道屏障功能的调节作用作一简要概述。Vitamin A plays important roles on maintaining epithelial barrier integrity,regulating mucosal immune function against several infections.Retinoic acid synthesizing enzymes（RALDH） is expressed in the gut-associated dendritic cells to produce RA.RA can up-regulate expression levels of integrin α4β7、CCR9 of T and B lymphocytes,which enhance the T and B lymphocytes preferentially homing to the small intestine and induce secretion of immunoglobulin-A（IgA）.RA also promotes the differentiation of native CD4＋T cells into Foxp3＋ inducible regulatory T cells（Treg）,and represses the proliferation of Th17 cells.Increasing evidences have demonstrated that vitamin A deficiency may decrease intestinal epithelial barrier function and down-regulate intestinal local mucosal immune responses,resulting in increased susceptibility of intestinal infection and risk of diarrhea.The current paper reviewed the regulatory effects of vitamin A on the intestinal barrier function.

关 键 词：维生素A 肠道屏障功能 黏膜免疫应答 

分 类 号：Q562[生物学—生物化学] R574[医药卫生—消化系统]