Synthesis of 6-(Bromomethyl)-4-methoxy-5,6,7,8-tetrahydropyrido-[3,2-d]pyrimidin-2-ol from 6-Methylpyrimidine-2,4-diol  

作　　者：LIU Wei-dong2, DENG Xi-ling2, ZHANG Zhi-li2, WANG Xiao-wei2 and LIU Jun-yi1,2 1. State Key Laboratory of Natural and Biomimetic Drug, 2. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P. R. China 

出　　处：《Chemical Research in Chinese Universities》2012年第1期57-60,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos.20672008, 20972011);the PhD Foundation of the Ministry of Education of China

摘　　要：6-（Bromomethyl）-4-methoxy-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-2-ol（compound 9） was synthe sized from 6-methylpyrimidine-2,4-diol（compound 1） through the crucial steps of 6-methyl alkylating and intramo lecular cyclization. The assignment of the structure of compound 9 was performed by its spectral data, 1H NMR, 13C NMR, HMBC, and HRMS spectra.6-（Bromomethyl）-4-methoxy-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-2-ol（compound 9） was synthe sized from 6-methylpyrimidine-2,4-diol（compound 1） through the crucial steps of 6-methyl alkylating and intramo lecular cyclization. The assignment of the structure of compound 9 was performed by its spectral data, 1H NMR, 13C NMR, HMBC, and HRMS spectra.

关 键 词：HETEROCYCLE CARBANION ALKYLATION Reduction CYCLIZATION 

分 类 号：O621.2[理学—有机化学]