顺铂腹腔灌注联合热化疗治疗宫颈癌  

Intraperitoneal application of chemotherapy in cervical cancer

作　　者：李雅琪[1] 龚勋[2] 罗连英[1] 马燕[1] 张瑜[1] 杨炜婷 吴忠秀[1] 廖国芳[1] 

机构地区：[1]凉山州第一人民医院妇产科,四川省西昌615000 [2]西昌学院

出　　处：《中国基层医药》2012年第2期203-204,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察腹腔热化疗治疗宫颈癌的临床疗效及不良反应。方法观察组40例接受多西他赛全身化疗＋顺铂腹腔灌注联合腹部高频热疗，对照组40例接受多西他赛＋顺铂全身化疗．观察其疗效及近期不良反应。结果观察组完全缓解率82．5％，有效率为92．5％；对照组分别为62．5％和75．0％。经过6个周期的化疗，观察组改善率85．0％，对照组改善率57．5％，两组差异有统计学意义（P〈0．05）；化疗过程中的主要毒副反应是胃肠道反应、白细胞减少、脱发．但两组差异无统计学意义（P〉0．05）。结论多西他赛全身化疗联合顺铂腹腔热灌注化疗可显著提高宫颈癌的治疗效果，且不增加毒副作用。Objective To observe the clinical efficacy and toxicity of intraperitoneal chemotherapy combined with intravenous cbemotherapy in treatment ofcervical cancer. Methods The experimental group of 40 patients received systemic chemotherapy of doeetaxel and cisplatin combined abdominal intrapefitoneal high-frequency hyperthennia in the control group,40 patients received docetaxel plus cisplatin chemotherapy,The efficacy and toxicity were observed. Results The complete remission rate of observotion group was 82.5%, significantly higher than 62.5% in control group. Effective rate in observation group was 92.5% and also significantly higher than 75.0% in control gronp. After 6 cycles of chemotherapy;the improvement of the experimental group was 85.0% higher than 57.5% in control gronp. The differemles between the two groups was statistically significant （ P 〈 0.05 ） ; the main side effects during chemotherapy are gastrointestinal reactions, since the ceils decreased, hair loss, the difference was not statistically significant （ P 〉 0.05 ）. Conclusion The chemotherapy of docetaxel and eisplatin intraperitoneal chemotherapy can significantly improve the treatment of cervical cancer,without increasing side effects. chemotherapy

关 键 词：宫颈肿瘤 腹腔热化疗 

分 类 号：R737.33[医药卫生—肿瘤]