亚洲人维生素D受体基因BsmI多态性与前列腺癌关系的Meta分析  

Association between Polymorphisms of VDR BsmI and Prostate Cancer in the Asian Population:A Meta-analysis

作　　者：李夏西[1] 侯祺[2] 曹加[1] 汪嬿如[1] 陆楷[1] 郑少斌[2] 罗荣城[1] 

机构地区：[1]南方医科大学,南方医院肿瘤中心,广东省广州市510515 [2]南方医科大学,南方医院泌尿外科,广东省广州市510515

出　　处：《中国全科医学》2012年第5期490-492,共3页Chinese General Practice

摘　　要：目的探讨亚洲人群维生素D受体(VDR)基因位点BsmI(rs1544410)多态性与前列腺癌易感性的关系。方法检索PubMed、EMBase、中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文科技期刊数据库(VIP)、万方数据平台从建库到2011年5月的文献,对所纳入的独立研究,运用RevMan 5.0.0软件进行Meta分析,Stata 11.0软件进行Begg's检验。结果共纳入6篇病例对照研究,累计样本量为1 890例,其中病例组796例,对照组1 094例。Meta分析结果表明,等位基因B对前列腺癌有保护作用〔OR=0.69,95%CI(0.55,0.88),P=0.002〕;基因型BB/Bb也能显著降低前列腺癌的发生率〔OR=0.64,95%CI(0.49,0.83),P=0.001〕。结论亚洲人群VDR基因位点BsmI多态性与前列腺癌易感性相关,等位基因B可能对前列腺癌发病起保护作用。Objective To investigate the association between VDR BsmI polymorphism（rs1544410） and prostate cancer in the Asian population.Methods PubMed,EMBase,CBM,CNKI,VIP,and Wanfang Data were searched for related clinical controlled trials.Meta-analysis was conducted by Revman 5.0.0 software,and Begg′s test was carried out using STATA 11.0 software.Results Six case-control studies（1 890 cases,including 796 patients and 1 094 controls） were included.According to meta-analysis,the B-allele displayed protective effects against prostate cancer（OR=0.69,95%CI（0.55,0.88）,P=0.002） while BB/Bb genotypes significantly reduce the incidence of prostate cancer（OR=0.64,95%CI（0.49,0.83）,P=0.001）.Conclusion VDR BsmI polymorphism is associated with the susceptibility of prostate cancer.B-allele and the BB/Bb genotypes may play protective roles against prostate cancer.

关 键 词：受体 骨化三醇 多态性 单核苷酸 前列腺肿瘤 META分析 

分 类 号：R737.25[医药卫生—肿瘤]