叶酸对结直肠腺瘤复发干预作用的随访研究  

Interventional Effects of Folic Acid on Recurrence of Colorectal Adenoma:Follow-up Study

作　　者：陈冬妹[1] 肖文[1] 张满芬[1] 

机构地区：[1]广东省中山市博爱医院消化内科,528400

出　　处：《中国全科医学》2012年第5期496-497,共2页Chinese General Practice

基　　金：广东省中山市医学科研基金(20102A041)

摘　　要：目的探讨叶酸预防结直肠腺瘤复发的作用。方法将104例结直肠息肉切除术后经病理证实为腺瘤者随机分为两组,治疗组46例除一般饮食指导外,给予叶酸口服;对照组58例予一般饮食指导。两组患者每年复查肠镜,随访2年。结果治疗组腺瘤复发率为26.1%(12/46),低于对照组的39.7%(23/58),两组差异无统计学意义(P>0.05);其中治疗组低叶酸水平者复发率为10.3%(3/29),低于对照组的47.2%(17/36),两组差异有统计学意义(P<0.05);治疗组高叶酸水平者复发率为52.9%(9/17),高于对照组的27.3%(6/22),两组差异无统计学意义(P>0.05)。结论补充叶酸可降低低叶酸水平结直肠腺瘤患者腺瘤复发风险,但对高叶酸水平结直肠腺瘤患者无干预作用,尚需进一步扩大样本量验证。Objective To explore the preventive effect of folic acid on the recurrence of the colorectal adenoma.Methods Totally 104 patients who underwent the resection of colorectal ployps and were confirmed as rectal adenoma by pathological examination were divided randomly into two groups：intervention group（n=46）,administered orally with folic acid in addition to the conventional diets;and control group（n=58）,administered with conventional diets.In the following two years,patients underwent colonoscopy each year to observe the intervention effects.Results The recurrence rate in the intervention group was 26.1%（12/46）,which was lower than that in the control group（39.7%,23/ 58）,but the difference was not statistically significant（P0.05）.The recurrence rate among patients with low folic acid level was 10.3%（3/29）in the intervention group and 47.2%（17/36） in the control group（P0.05）.The recurrence rate among the patients with high folic acid level was 52.9%（9/17）in intervention group and 27.3%（6/22）in the control group（P0.05）.Conclusion Oral administration of folic acid can lower the recurrence risk of the colorectal adenoma in patients with low level of folic acid,but has no such preventive effect in patients with high level folic acid.

关 键 词：叶酸 腺瘤 结肠 直肠 复发 随访研究 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]