超分子体系中的分子识别研究(一)──氨基酸修饰β-环糊精对客体分子TNS的包结配位研究  

Molecular Recognition Studies on Supramolecular Systems(一) Inclusion Complexation of the Novel Amino Acid Modified β-CDs with TNS

作　　者：靳兰[1] 孙世 新刘育 

机构地区：[1]南开大学化学系,天津300071

出　　处：《高等学校化学学报》2000年第3期412-414,共3页Chemical Journal of Chinese Universities

基　　金：国家杰出青年基金!(批准号 :2 96 2 5 2 0 3);中国博士后基金!(批准号 :1999-10 )

摘　　要：The fluorescence spectra have been studied in phosphate buffer aqueous solution(pH=7.20) to give the stability constants( K s) for the supramolecular system formed by L Pro β CD(1), L Leu β CD(2), and L Ileu β CD(3) with TNS. The results obtained indicate that the binding ability of modified β cyclodextrins(1) with TNS is larger than that of 2 and 3. One possible explanation is that there are different substitutes among the three modified β cyclodextrins.The molecular binding ability is discussed from the size fit concept between the host and the guest molecules. The results indicate that the substitute on the side arm attached to the edge of β CD plays a crucial role in guest inclusion.The fluorescence spectra have been studied in phosphate buffer aqueous solution(pH=7.20) to give the stability constants( K s) for the supramolecular system formed by L Pro β CD(1), L Leu β CD(2), and L Ileu β CD(3) with TNS. The results obtained indicate that the binding ability of modified β cyclodextrins(1) with TNS is larger than that of 2 and 3. One possible explanation is that there are different substitutes among the three modified β cyclodextrins.The molecular binding ability is discussed from the size fit concept between the host and the guest molecules. The results indicate that the substitute on the side arm attached to the edge of β CD plays a crucial role in guest inclusion.

关 键 词：Β-环糊精 氨基酸修饰 包结作用 分子识别 

分 类 号：O636.12[理学—高分子化学] O621.15[理学—化学]