内肥素与儿童青少年肥胖、非酒精性脂肪肝的关联研究  

Relationship between serum visfatin level and children and adolescent obesity and non-alcoholic fatty liver disease

作　　者：文晗[1] 王海俊[1] 董彬[1] 马军[1] 

机构地区：[1]北京大学公共卫生学院/儿童青少年卫生研究所,100191

出　　处：《中华流行病学杂志》2012年第3期269-272,共4页Chinese Journal of Epidemiology

基　　金：教育部博士点基金（200800010067）

摘　　要：目的探讨血清内肥素与儿童青少年肥胖、非酒精性脂肪肝（NAFLD）的关联。方法采用双抗体夹心ELISA法，测定69名体重正常无NAFLD和106名肥胖儿童青少年（肥胖无NAFLD49名及合并NAFLD57名，其中轻度42名、中重度15名）的血清内肥素水平。结果体重正常组与肥胖组血清内肥素水平分别为（1．75±0．37）、（1．71±O．37）ng／ml，差异无统计学意义（P=O．455）；肥胖儿童青少年血清内肥素水平随着脂肪肝程度的加重而上升[肥胖无NAFLD组为（1．59±0．36）ng／ml、肥胖合并轻度NAFLD组为（1．74±0．36）ng／ml、肥胖合并中重度NAFLD组为（1．97±0．36）ng／ml，三者之间差异有统计学意义（P〈0．05）]，与年龄（β=0．326，P=0．000）、丙氨酸转氨酶活性（β=0．286，P=0．004）相关，不同程度NAFLD者内肥素水平差异有统计学意义（β=0．246，P=0．014）。结论肥胖儿童青少年中血清内肥素水平与NAFLD相关。Objective To examine the relationships between the level of serum visfatin and obesity, nonalcoholic fatty liver disease （NAFLD） in children and adolescents. Methods Serum visfatin levels of 106 obese children/adolescents （including 49 non-NAFLD children and adolescents and 57 NAFLD children/adolescents in which consisting of 42 mild ones, 15 moderate-to-severe ones） with another 69 lean children/adolescents as their controls, were examined by indirect sandwich ELISA. Results When comparing the serum visfatin levels, there was no significant difference noticed between the obese group （1.71 ± 0.37） ng/ml and the lean group （1.75 ±0.37） ng/ml （P= 0.455）. With the severity of NAFLD, the serum visfatin level showed an elevation in obese children and adolescents [obese without NAFLD （ 1.59± 0.36） ng/ml, obese with mild NAFLD （ 1.74 ± 0.36） ng/ml, obese with moderate-to-severe NAFLD （1.97± 0.36） ng/ml, P〈0.05]. In the obese group, serum visfatin levels seemed to be related to age （β =-0.326, P=0.000）, alanine aminotransferase （ALT） （β =0.286, P=0.004）and the degree of NAFLD （β=0.246, P=0.014）. Conclusion The level of serum visfatin was related to non-alcoholic fatty liver in obese children and adolescent.

关 键 词：内肥素 肥胖 脂肪肝 儿童 

分 类 号：R575.5[医药卫生—消化系统]