Salen和Salan配体的合成  

Synthesis of Salen and Salan ligands

作　　者：程涛[1] 刘雪红[1] 申东升[1] 刘丰收[1] 

机构地区：[1]广东药学院医药化工学院,广东广州510006

出　　处：《广东药学院学报》2011年第6期575-578,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：广州市番禺区科技攻关项目资助(2010-z-13-1)

摘　　要：目的与方法以水杨醛、叔丁基水杨醛、邻苯二胺、乙二胺为原料,经缩合反应合成了4个Salen配体和4个Salan配体,其中2个Salan配体为未见文献报道的新化合物。结果与结论目标化合物均经1H-NMR、13C-NMR进行表征并归属确证结构;该合成方法的原料便宜,操作简单,适合大批量生产。Objective and Methods To establish a new route for the synthesis of Salen and Salan ligands.Salen and Salan ligands were synthesized at different temperature,using salicylaldehyde,tert-butyl salicylaldehyde,o-phenylenediamine and ethylenediamine as starting materials.Results and Conclusion 4 Salan and 4 Salen ligands were obtained.The structure was confirmed by 1H-NMR and 13C-NMR analysis.2 new Salen ligands were syntheiszed.The improved procedure has the advantages of low costing of starting material,and the route is convenient and simple,which is suitable for large scale of production.

关 键 词：Salan配体 SALEN配体 席夫碱 缩合反应 还原反应 

分 类 号：R914[医药卫生—药物化学]