TGF-β1在口腔扁平苔藓及鳞癌中的表达  

The expression of TGF-β1 in oral lichen planus and squamous cell carcinoma

作　　者：孙维克[1,2] 戚向敏[1] 

机构地区：[1]山东大学口腔医学院口腔内科,济南市250012 [2]滨州医学院口腔学院,滨州市256603

出　　处：《滨州医学院学报》2011年第6期410-413,共4页Journal of Binzhou Medical University

摘　　要：目的探讨TGF?β1在口腔扁平苔藓、鳞癌发病中的作用及口腔扁平苔藓的癌变机制。方法应用免疫组化法,检测TGF?β1在口腔扁平苔藓、口腔鳞癌中的表达,并用半定量评估法,采用SPSS13.0统计软件对数据进行等级资料的非参数检验。结果 30例口腔扁平苔藓主要呈弱阳性表达,固有层淋巴细胞呈散在阳性;30例口腔鳞癌中13例呈阴性表达,其余多呈弱阳性,二者均与正常口腔黏膜强阳性相比表达明显下调(P<0.05)。但部分口腔癌呈强阳性表达,主要分布在癌的纤维间质中。结论 TGF?β1表达下调激活淋巴细胞导致口腔黏膜局部免疫功能紊乱是引起扁平苔藓发病的重要因素;TGF?β1表达的量和分布的变化促进口腔鳞癌的生长与侵袭,且与口腔扁平苔藓癌变有关。Objective To study the function of TGF-β1 in oral lichen planus（OLP）and oral squamous cell carcinoma（OSCC）and the mechanism of the canceration of oral lichen planus.Methods Immunohistochemical method was used to study the expression and significance of TGF-β1 in OLP and OSCC,and Semiquantitative method was used to assess,SPSS13.0 statistical software was used to conduct data nonparametric test for rank data.Results The expression of TGF-β1 in 30 cases of OLP almost was weak positive,while scattered positive in lymphocytes in Lamina propria.TGF-β1 was negative in 13 cases of OSCC,and weak positive in the rest cases.It was down-regulated in OLP and OSCC compared with normal oral mucosa（NOM）（P0.05）.While the expression of TGF-β1 in parts of OSCC was strong positive,alimost located in the fibrous stroma.Conclusions The down-regulated expression of TGF-β1 may active lymphocytes,and lead to the disorder of immunity in local oral mucosa.TGF-β1 plays an important role in the incidence of OLP.The change of quantity and location of the TGF-β1 expression promotes the growth and Infiltration of OSCC,and may be associated with the carcinogenesis of OLP.

关 键 词：TGF-Β1 口腔扁平苔藓 鳞癌 癌变 

分 类 号：R780.2[医药卫生—口腔医学]