环孢素治疗激素耐药型肾病综合征的研究进展  

Study Progress of Cyclosporine Therapy on Steroid-Resistant Nephrotic Syndrome in Children

作　　者：易玲[1] 任榕娜[1,2] 余自华[1,2] 

机构地区：[1]福建医科大学福总临床医学院儿科,福州350025 [2]南京军区福州总医院儿科,福州350025

出　　处：《实用儿科临床杂志》2012年第5期371-374,共4页Journal of Applied Clinical Pediatrics

基　　金：福建省自然科学基金(2006J0119);南京军区医学科学技术研究"十一五"计划课题(06MA148;06MA151);2008年度南京军区医学科技创新课题(08MA102)

摘　　要：儿童激素耐药型肾病综合征(SRNS)的治疗相对棘手,目前治疗上常用的免疫抑制剂有环孢素(CsA)、环磷酰胺、他克莫司等。CsA的药物代谢动力学不稳定,需定期监测其血药水平。CsA对SRNS儿童的诱导缓解率优于安慰剂及环磷酰胺,与他克莫司相当。SRNS儿童在CsA停药后易出现复发,其复发率为45%～64%。为增强CsA的疗效、减少其肾毒性,推荐应用小剂量、长疗程CsA治疗儿童SRNS的方案。Management of steroid-resistant nephrotic syndrome（SRNS） in children is challenging.Immunosuppressive agents are the commonly used treatment strategies,such as cyclosporine A（CsA）,cyclophosphamide,tacrolimus,and so on.Because of the unstable pharmacokinetic of CsA,regular drug monitoring of CsA is mandatory.CsA is more effective than placebo or cyclophosphamide,and shows similar efficacy with tacrolimus in inducing remission in SRNS children.The relapsing rate of children with SRNS is high after drug withdrawal,which is from 45% to 64%.To enhance the efficacy and reduce the nephrotoxicity,long-term CsA therapy in low doses is recommended in the treatment of children with SRNS.

关 键 词：环孢素 激素耐药型肾病综合征 儿童 

分 类 号：R726.91[医药卫生—儿科]