注射用头孢匹胺与注射用氯诺昔康配伍的稳定性研究  

Stability and compatibility of cefpiramide and lornoxicam in 0.9% sodium chloride injection

作　　者：方宝霞[1] 陈富超[1] 朱军[1] 李鹏[1] 林洁[1] 杨盼鑫[2] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008 [2]湖北医药学院药学院,湖北十堰42000

出　　处：《安徽医药》2012年第2期160-162,共3页Anhui Medical and Pharmaceutical Journal

基　　金：十堰市科学技术研究与开发计划项目(No 2010ST45)

摘　　要：目的考察注射用头孢匹胺与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法在[(25±1)℃]下,观察和检测两药配伍液在8 h内的外观及pH值变化,并用高效液相色谱法(HPLC)测定配伍液中头孢匹胺与氯诺昔康的含量变化。结果 8 h内配伍液外观、pH值及氯诺昔康的含量无明显变化,头孢匹胺含量不断下降,8 h含量为96.5%。结论室温条件下,注射用头孢匹胺与注射用氯诺昔康在0.9%氯化钠注射液中8 h内保持稳定。Objective To evaluate the stability and compatibility of cefpiramide for injection with lornoxicam in 0.9%sodium chloride injection.Methods At room temperature[（25±1）℃],the changes in contents of cefpiramide and lornoxicam were determined simultaneously by HPLC,and the changes in appearance,pH value were observed within 8 hours.Results No significant differences were found in appearance,pH value and the content of lornoxicam for the mixed solution within 8 hours.The content of cefpiramide evidenly decreased over 8 hours,with 96.5% of the initial concentration.Conclusion The mixture of cefpiramide for injection with lornoxicam in 0.9%sodium chloride injection at ambient temperature is stable within 8 hours.

关 键 词：头孢匹胺 氯诺昔康 配伍 稳定性 HPLC 

分 类 号：R942[医药卫生—药剂学]