碱性成纤维细胞生长因子在胃肠道间质瘤中的表达及临床意义  

Expression and Clinical Significance of b-FGF in Gastrointestinal Stromal Tumors

作　　者：田志宏[1] 黄博[1] 冯变喜[1] 

机构地区：[1]山西省人民医院,山西太原030001

出　　处：《山西职工医学院学报》2012年第1期11-13,共3页Journal of Shanxi Medical College for Continuing Education

摘　　要：目的:研究碱性成纤维细胞生长因子(basic fibroblast growth factor,b-FGF)在胃肠道间质瘤(gastroin-testinal stromal tumors,GIST)中的表达及临床意义。方法:采用免疫组织化学法检测50例GIST中b-FGF的表达情况。结果:GIST中b-FGF表达阳性的组织微血管密度(microvessel density,MVD)显著高于表达阴性的MVD(P<0.05);b-FGF表达阳性者肿瘤直径显著大于b-FGF表达阴性者(P<0.05);b-FGF的表达与GIST的发生部位、核分裂多少、恶性潜力呈显著相关(均P<0.05)。结论:b-FGF是GIST的生物学行为和预后的重要标记物,阳性表达者恶性程度高,预后不良。Objective：To explore the expression and clinical significances of basic fibroblast growth factor（b-FGF） in gastrointestinal stromal tumors （GIST）. Methods： Samples of 50 cases with GIST were examined by immunohistochemical staining S-P method for the expression of b-FGF. Results： The density of microvessel density （ MVD ） in positive b- FGF cases was significantly higher than that in negative b-FGF cases （P 〈 0.05 ）. The diameter of tumors in positive b- FGF cases was obviously bigger than that in negative b-FGF cases （P 〈 0.05）. The expression of b-FGF significantly correlated with the site of tumor growing （ P 〈 0.05 ）, the amount of karyoclasis （ P 〈 0.05 ） and the malignant potential of GIST （ P 〈 0. 05 ）. Conclusions ： b-FGF is an important marker reflecting the biological behaviors and prognosis of gastrointestinal stromal tumors. The positive expression of b-FGF suggests higher maligance and poor prognosis.

关 键 词：胃肠道间质瘤 碱性成纤维细胞生长因子 微血管密度 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]