胰腺癌化疗前后血清IGF-Ⅱ和TGF-α检测及临床意义  

Clinical significance of determination of change of serum IGF-Ⅱ and TGF-α levels after chemotherapy in patients of pancreatic cancer

作　　者：侯亚莉[1] 华克胜[2] 

机构地区：[1]菏泽医学专科学校病理科,山东菏泽274000 [2]山东省菏泽市立医院胸外科,山东菏泽274000

出　　处：《中国现代医生》2012年第8期109-110,共2页China Modern Doctor

摘　　要：目的观察胰腺癌患者化疗前后血清IGF-Ⅱ及TGF-α的水平变化,并探讨其对复发的临床意义。方法通过放射免疫分析法测定35例胰腺癌患者化疗前、化疗后1个月及化疗后6个月的血清IGF-Ⅱ及TGF-α水平,并与35名正常健康人作比较。结果胰腺癌患者化疗前血清IGF-Ⅱ及TGF-α水平明显高于正常人(P<0.01);化疗后1个月时IGF-Ⅱ及TGF-α水平明显降低(P<0.01);化疗后6个月时,复发患者的IGF-Ⅱ及TGF-α水平明显高于未复发者(P<0.01)。结论血清IGF-Ⅱ及TGF-α水平检测有助于判断化疗疗效、预测复发。Objective To observe the changes of serum IGF-Ⅱ and TGF-α in patients with pancreatic cancer before and after chemotherapy, so as to explore the clinical significance to recurrence. Methods The serum IGF-Ⅱ and TGF-α n 35 patients with pancreatic cancer were detected before and after chemotherapy for one month and six months, as well as in 35 normal controls. Results Compared with those of before chemotherapy, the level of serum IGF-Ⅱ and TGF-α decreased dramatically in patients after chemotherapy for one month （P 〈 0.01）. But the level of serum IGF-Ⅱ and TGF-α after chemotherapy for six months were significantly higher in patients with recurrence compared with those without recurrence （P 〈 0.01）. Conclusion Detection of serum IGF--Ⅱ and TGF-α was helpful to judge the chemotherapy effect and to fore- cast the recurrence.

关 键 词：IGF-Ⅱ TGF-Α 胰腺癌 化疗前后 

分 类 号：R735.9[医药卫生—肿瘤]