肝素对内毒素所致大鼠肝损伤的保护作用  

The protective effect of heparin in endotoxin-induced liver injury of rat

作　　者：秦华丽[1] 李晓花[2] 

机构地区：[1]南京农业大学医院,江苏南京210095 [2]东风公司茅箭医院

出　　处：《中外医学研究》2012年第7期140-141,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨肝素对内毒素所致大鼠肝损伤的保护作用。方法:腹腔注射6mg/kg脂多糖(LPS)复制大鼠肝损伤模型,肝素组腹腔注射120U/kg肝素预防。5h后取血,利用全自动生化仪检测乳酸脱氢酶(LDH)、谷丙转氨酶(ALT)、谷草转氨酶(AST)等指标,光镜下观察肝脏病理学改变。结果:与对照组相比,模型组生化指标LDH、ALT、AST均明显升高(P<0.01),光镜下肝窦及间质血管充血明显。肝素组各项指标较模型组均明显改善(P<0.01),肝窦及间质血管充血减轻。结论:肝素能够减轻内毒素所致的大鼠肝损伤。Objective ： To investigate the protective effect of heparin in endotoxin - induced liver injury. Methods： The model of liver in- jury established with LPS （6 mg/kg） by intraperitoneal injection. Heparin group were injected with LPS（6 mg/kg） and heparin（ 120 U/kg）. The blood sample was taken after 5 h. To detect LDH,ALT and AST by Olympus biochemical autoanalyzer;Then take out the liver and observe pathol- ogy change of the tissue section. Results： Compared with control group： experimental data from model group indicated that LDH, ALT and AST obviously changed（ P 〈 0. 01 ）. Liver biopsy showed vascular engorgement. All the biochemical indicators ameliorated among heparin group than model group （P 〈 0.01 ） ,while pathological change was alleviated in liver. Conclusion ：This study shows that heparin can attenuate the endotox- in - induced liver injury in the pathogenesis of rat.

关 键 词：肝素 内毒素 肝损伤 

分 类 号：R575[医药卫生—消化系统]