ALA光动力疗法治疗皮肤鳞状细胞癌的临床研究  

The clinical research of ALA photodynamic therapy for squamous cell carcinoma

作　　者：颉玉胜[1] 陈燕[2] 彭学标[3] 范文成[1] 宋维旭[1] 瞿平原[4] 魏翠萍[1] 

机构地区：[1]兰州军区兰州总医院安宁分院皮肤美容科,甘肃兰州730070 [2]兰州军区兰州总医院血液科,甘肃兰州730070 [3]南方医科大学南方医院皮肤科,广东广州510515 [4]甘肃省肿瘤医院门诊部,甘肃兰州730070

出　　处：《中国美容医学》2012年第3期453-454,共2页Chinese Journal of Aesthetic Medicine

基　　金：甘肃省自然科学基金资助课题(项目编号:1107RJZA109)

摘　　要：目的:观察5-氨基酮戊酸光动力疗法(ALA-PDT)治疗皮肤鳞状细胞癌的临床疗效和复发率。方法:对30例经组织病理学确诊的皮肤鳞状细胞癌进行了4～11次ALA-PDT治疗,并与经手术治疗的30例患者进行复发率的比较。结果:治疗组29例患者获完全缓解,临床治愈。经6～12月随访后,4例复发;对照组5例复发,统计学处理无显著性差异(P>0.05)。但光动力组美容效果满意。结论:对皮肤鳞状细胞癌尤其老年患者,ALA-PDT疗法损伤小、美容效果好,复发率与手术方法相当(P>0.05)。Objective To observe the clinical efficacy and relapse rate of the 5-aminolevulinic acid photodynamic therapy （ALA-PDT） for squamous cell carcinoma. Methods 30 patients with squamous cell carcinoma diagnosed by histopathological examination were treated by ALA-PDT for 4 to 11 times,and comparied with those patients who were treated by surgery for a relapse rate. Results The complete remission were achieved in 29 patients from treatment group, and that were considered up to clinical cure. After 6 to 12 month follow-up, 4 cases from treatment group and 5 cases from control group were found to relapse, there was no statistical significant difference （P〉0.05）.However, satisfactory cosmetic results were achieved in treatment group by ALA-PDT.Conclusion For those patients with cutaneous squamous cell carcinoma,especially for elderly ones, the recurrence rate of ALA-PDT was similar to that of surgical methods,but ALA-PDT had the advantage of less damage and better cosmetic results.

关 键 词：5-氨基酮戊酸 光动力 鳞状细胞癌 复发率 

分 类 号：R739.5[医药卫生—肿瘤]