血清PG和G-17及幽门螺杆菌抗体表达与胃癌发病率相关性分析  

Analysis on the expression of serum PG,G-17 and helicobacter pylori antibody and incidence of gastric cancer

作　　者：郑奎城[1,2] 林曙光[1] 李晓庆[1] 钟文玲 陈铁晖[1] 苏畅[1] 胡祥炬[1] 林丹[1] 戴龙[3] 陈仁忠[3] 陈上清[3] 游建旺 林嵩[5] 

机构地区：[1]福建省疾病预防控制中心慢病科,福建福州350001 [2]福建医科大学公共卫生学院教学基地,福建福州350001 [3]厦门市疾病预防控制中心慢病科,福建厦门361021 [4]长乐市疾病预防控制中心慢病科,福建长乐350200 [5]福安市疾病预防控制中心慢病科,福建福安355000

出　　处：《中华肿瘤防治杂志》2012年第1期24-27,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：日本学术振兴会(JSPS)项目(基盘研究B18406022)

摘　　要：目的:探讨福建省胃癌高、中、低发地区居民血清胃蛋白酶原(PG)Ⅰ、PGⅡ、胃泌素(G-17)水平及幽门螺杆菌(Hp)感染的分布趋势。方法:选择长乐市江田镇、同安区大同镇和福安市赛歧镇分别代表福建省胃癌的高、中、低发地区,以ELISA检测3地区居民(共725人)的血清PGⅠ、PGⅡ、G-17含量及Hp IgG抗体,统计学检验比较各指标在3地区间的差异。结果:长乐江田镇、同安大同镇和福安赛歧镇PGⅠ中位数分别为110.75、131.00和107.32μg/L,PGⅡ为13.90、14.70和7.79μg/L,PGⅠ/PGⅡ比值为7.91、8.66和13.09,G-17为2.90、1.10和1.00ρmol/L,Hp感染率分别为49.6%、33.5%和29.3%。各指标在3个地区间的差异均有统计学意义,z值为47.15～121.76,χ2=22.47,P值均<0.001。3地区居民血清指标异常者(PGI<25μg/L、PGⅠ/PGⅡ比值<2.5或G-17≥2ρmol/L)所占的比例差异有统计学意义,χ2值为13.45～94.46,P值均≤0.001。Hp感染阳性者的血清PGⅠ、PGⅡ和G-17均高于阴性者,而PGⅠ/PGⅡ比值则低于阴性者。无论Hp阳性或阴性,3个地区居民的血清学指标差异都有统计学意义,z值为-3.32～70.36,P值均<0.05。结论:福建省胃癌高、中、低发地区居民血清PGⅠ、PGⅡ、G-17水平及Hp感染率分布有明显的地区差异,提示这些血清学指标的变化可能与胃癌的发生密切相关。OBJECTIVE： To compare serum pepsinogen （PG） Ⅰ , Ⅱ ,gastrin （G-17） and Helicobacter pylori （Hp） antibody in areas with high,medium and low incidence of gastric cancer in Fujian Province,and to explore the distribution of these parameters in local residents. METHODS： Jiangtian Town in Changle City,Datong Town in Tongan District and Saiqi Town in Fuan City were selected to represent the areas with high,medium and low incidence of gastric cancer in Fu- jian Province respectively. The concentrations of serum PG Ⅰ ,Ⅱ , G-17 and Hp antibody were determined by usingELISA and the results of these parameters were compared among three areas （n= 725）. RESULTS： The concentrations of serum PG Ⅰ were 110.75,131.00 and 107.32μg/L,PGH were 13.90,14.70 and 7.79 μg/LandtheratiosofPGI/PG Ⅱ were 7.91,8.66 and 13.09 in Jiangtian Town,Datong Town and Saiqi Town respectively. The serum concentrations of G-17 were 2.90,1.10 and 1.00 pmol/L,and the positive rates of Hp infection were 49.60/oo,33.50/oo and 29.3% in Jiangtian Town,Datong Town and Saiqi Town respectively. These parameters were significantly different among three areas （z=47.15--121.76,P≤0.001;X2=22. 47,P≤0. 001）. The percentages of the residents withPG I（ 25 μg/L,PGI/ PGH （ 2.5 or G-17 ≥ 2 pmol/L were significantly different in three areas as well （X2 =13.45-94.46,P≤0. 001）. The concentrations of serum PG I , Ⅱ and G-17 in the subjects with Hp infection were significantly higher than those without Hp infection,but the ratios of PG I/PG Ⅱ were lower than those without Hp infection. No matter Hp infection or not were these parameters significantly different among three areas （z=-3.32-70.36, P〈0.05）. CONCLUSION： The dis- tributions of PG I ,PG Ⅱ ,G-17 and Hp infection rates among areas with high,medium and low incidence of gastric canc- er are significantly different,which implys that these parameters may be closely related to gastric cancer.

关 键 词：胃肿瘤 胃蛋白酶原A 胃蛋白酶原B 胃泌素类 螺杆菌 幽门 抗体 

分 类 号：R735.2[医药卫生—肿瘤]