网络药理学:认识药物及发现药物的新理念  

Network pharmacology-a new philosophy for understanding of drug action and discovery of new drugs

作　　者：周文霞[1] 程肖蕊[1] 张永祥[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学与毒理学杂志》2012年第1期4-9,共6页Chinese Journal of Pharmacology and Toxicology

基　　金：国家"重大新药创制"科技专项(2012ZX09301003-002-001);国家重点基础研究发展计划(973计划)项目(2004CB518907);国家自然科学基金(30973541);国家自然科学基金(30772562)~~

摘　　要：网络药理学是指将药物作用网络与生物网络整合在一起,分析药物在此网络中与特定节点或模块的相互作用关系,从而理解药物和机体相互作用的科学。网络药理学突破传统的"一个药物一个靶标,一种疾病"理念,代表了现代生物医药研究的哲学理念与研究模式的转变。以系统生物学和网络生物学基本理论为基础的网络药理学具有整体性、系统性的特点,注重网络平衡(或鲁棒性)和网络扰动,强调理解某个单一生物分子(如基因、mRNA或蛋白等)在生物体系中的生物学地位和动力学过程要比理解其具体生物功能更为重要,揭示药物作用的生物学和动力学谱要比揭示其作用的单个靶标或几个"碎片化"靶标更重要,对认识药物和发现药物的理念产生了深远影响。Network pharmacology investigates the interaction between the drug and body by mapping drug-target（polypharmacology） networks onto biological networks.Network pharmacology challenges the traditional concept ＂one disease,one target,one drug＂,and represents the modern philosophy and pattern of biomedical research as a new branch of pharmacology.Based on systems biology and network biology,network pharmacology with holistic and systemic features is focused on network equilibrium（or robustness） and network disturbance.Understanding the status,fundamental dynamics and kinetics of individual biological molecules in the biological network is more important than the specific biological function.Understanding the biological and kinetic profile of the drug is more important than individual validation of targets or combinations of targets.Network-based drug discovery is to create new drugs-regulating networks.Network pharmacology has profound influence on the philosophy of clinical drug therapeutics and drug discovery.

关 键 词：网络药理学 多向药理学 鲁棒性 网络扰动 动力学 

分 类 号：R96[医药卫生—药理学]