EmbryoGlue移植液对体外受精-胚胎移植后胚胎种植及妊娠结局的影响  

Influence of EmbryoGlue on the implantation of embryo and pregnancy outcome in vitro fertilization-embryo transfer

作　　者：吴芳[1] 吕睿[1] 白晓红[1] 宋学茹[1] 

机构地区：[1]天津医科大学总医院生殖医学中心,300052

出　　处：《中华妇产科杂志》2012年第2期121-124,共4页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的 探讨EmbryoGlue移植液对体外受精-胚胎移植（IVF-ET）后胚胎种植及妊娠结局的影响.方法 回顾性分析2010年8月至201 1年1月在天津医科大学总医院生殖医学中心接受常规体外受精（IVF）或单精子卵细胞胞质内注射（ICSI）治疗的243例不孕患者的临床资料,选择使用EmbryoGlue胚胎移植液的129例患者为观察组,使用G-2胚胎移植液的114例患者作为对照组.比较两组患者妊娠结局.结果 （1）观察组和对照组患者的年龄、IVF/ICSI构成比、既往失败周期数及病因构成比较,差异均无统计学意义（P均＞0.05）.（2）观察组患者胚胎种植率30.4％ （85/280）,对照组18.8％（48/255）,两组比较,差异有统计学意义（P＜0.05）；观察组临床妊娠率48.8％ （63/129）,对照组34.2％（39/114）,两组比较,差异有统计学意义（P＜0.05）；观察组多胎妊娠率34.9％（22/63）,对照组20.5％（8/39）,两组比较,差异有统计学意义（P＜0.05）；观察组异位妊娠率4.8％（ 3/63）,对照组17.9％ （7/39）,两组比较,差异有统计学意义（P＜0.05）.结论 在IVF-ET中EmbryoGlue移植液可以促进胚胎种植,并可降低异位妊娠的发生.Objective To study the influence of EmbryoGlue on the implantation of embryo and pregnancy outcome in vitro fertilization （IVF）-embryo transfer （ET）.Methods From August 2010 to January 2011,243 infertile patients in Reproductive Medical Center of Tianjin Medical University General Hospital who underwent IVF or intracytoplasmic sperm injection （ICSI） were divided into two groups,including 129 cases used EmbryoGlue as the embryo transfer medium in experimental group and 114 cases used G-2 as embryo transfer medium in control group.Pregnancy outcome were compared between two groups.Results （1） The female age,IVF/ICSI constituent ratio,previous failure cycles and infertile factors of patients did not show statistical difference between experimental group and control group （P 〉0.05 ）.（2） The implantation rate of women in experimental group increased significantly compared with the control group [ 30.4% （ 85/280 ） vs.18.8% （ 48/255 ）,P 〈 0.05 ] ; Clinical pregnancy rate increased significantly compared with the control group [48.8% （63/129） vs.34.2% （39/114）,P 〈0.05] ; Multiple pregnancy rate increased significantly compared with the control group [ 34.9% （22/63） vs.20.5%（8/39）,P 〈 0.05 ] ; Ectopic pregnancy rate decreased significantly compared with the control group [ 4.8%（3/63） vs.17.9% （ 7/39 ）,P 〈 0.05 ].Conclusion EmbryoGlue can facilitate embryo implantation in IVF-ET and reduce the occurrence of ectopic pregnancy.

关 键 词：受精 体外 胚胎移植 胚胎植入 妊娠率 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]