原发韦氏环黏膜相关淋巴组织淋巴瘤的临床特点和长期治疗结果  

Primary mucosa-associated lymphoid tissue lymphoma of Waldeyer＇s ring： clinical characteristics andlong-term outcome

作　　者：吴润叶[1] 李晔雄[1] 亓姝楠[1] 刘清峰[1] 金晶[1] 王维虎[1] 宋永文[1] 王淑莲[1] 刘跃平[1] 任骅[1] 房辉[1] 等专专[1] 张希梅[1] 陈波[1] 刘新帆[1] 余子豪[1] 

机构地区：[1]中国医学科学院北京协和医学院肿瘤医院肿瘤研究所放疗科,北京100021

出　　处：《中华放射肿瘤学杂志》2012年第2期149-151,共3页Chinese Journal of Radiation Oncology

摘　　要：目的分析原发韦氏环黏膜相关淋巴组织（MALT）淋巴瘤的临床特点和长期治疗结果。方法回顾分析本院初治的10例原发韦氏环MALT淋巴瘤，其中男1例、女9例，Iε期7例、ⅡE期3例。单纯放疗3例，7例在放疗前加1-4周期化疗或再加辅助化疗。放疗中位剂量40Gy，化疗方案以CHOP方案为主。结果中位年龄58岁，均无全身症状，只有1例乳酸脱氢酶升高。疗后完全缓解率100％。中位随访90个月，全组5年总生存率、疾病相关生存率和无进展生存率分别为90％、100％和80％。1例死于直肠癌肝转移，1例脑部复发经放疗挽救治愈。结论韦氏环MALT淋巴瘤与其他胃外MALT淋巴瘤有类似临床特点，放疗为主的治疗取得了出色的长期疗效。Objective To investigate the clinical characteristics and long-term outcome of patients with mucosa-associated lymphoid tissue （MALT） lymphoma of Waldeyer＇s ring. Methods Ten patients were retrospectively analyzed. Seven patients had stage It and 3 patients had stage IIE disease. All patients received radiation therapy with a median dose of 40 Gy, and 7 patients also received 1 to 4 cycles of CHOP- based chemotherapy before radiation. Results The ratio of male to female was 1 ： 9. The median age was 58 years. No patient had B symptoms. One patient had elevated LDH level. The complete response rate after treatment was 100%. With median follow-up periods of 90 months, 1 patient died from rectal cancer. One patient developed brain metastasis and was salvaged by radiotherapy. The 5-year overall survival, cancer specific survival and progression-free survival rates were 90% , 100% and 80% , respectively. Conclusions The clinical characteristics of Waldeyer＇s ring MALT lymphoma were similar to that of nongastric MALT lymphoma. For patients with Waldeyer＇s ring MALT lymphoma, primary radiotherapy can result in excellent long-term survival.

关 键 词：原发韦氏环 黏膜相关淋巴组织 淋巴瘤 临床特点 治疗 

分 类 号：R733.1[医药卫生—肿瘤]