低、高频闭环电刺激对氯化铁癫痫模型大鼠治疗作用的比较  

Comparison between therapeutic effects of low-and high-frequency electric closed-loop stimulation on the ferric chloride-induced seizures in rats

作　　者：孙杨[1] 李桀[1] 井晓荣[1] 王超[1] 梁秦川[1] 李焕发[1] 张华[1] 高国栋[1] 

机构地区：[1]西安市第四军医大学唐都医院神经外科,在读研究生710038

出　　处：《立体定向和功能性神经外科杂志》2011年第6期347-349,共3页Chinese Journal of Stereotactic and Functional Neurosurgery

摘　　要：目的探讨低、高频闭环电刺激对氯化铁癫痫模型大鼠的治疗效果。方法给予SD大鼠头颅额、顶、枕部铺设硬膜外电极6枚,用立体定向方法在大鼠感觉运动皮质区注入氯化铁溶液,建立癫痫模型,分别给予低频刺激(1Hz)和高频刺激(100Hz),同时给予8小时脑电监测。分析大鼠8小时内发作总次数和发作总时间。结果低频和高频电刺激均能抑制大鼠的癫痫发作,而高频与低频刺激在治疗效果上无明显统计学差异。结论低频刺激为较佳的刺激方式。Objective Comparison between therapeutic effects of low-and high-frequency electric closed-loop stimulation on the ferric chloride-induced seizures in rats.Methods SD rats respectively received implantation of 6 epidural electrodes placed in frontal parietal and occipital regions of cranium.To establish an acute epilepsy model,FeC13 was injected into sensori motor cortxe of rats with stereotactic technique.Were given low-frequency stimulation(1Hz) and high-frequency stimulation(100Hz),while giving eight hours EEG monitoring.Analysis of rats duration time and number of seizures.Results The duration time and number of seizures in 1-Hzor 100-Hz groups was apparently shorter than that in the control group.The high frequency and low frequency stimulation in the treatment effect was no significant difference.Conclusion Comparison with high-frequency stimulation,low-frequency stimulation is better for Clinical application.

关 键 词：氯化铁 癫痫 大鼠 电刺激 低频 高频 

分 类 号：R742.1[医药卫生—神经病学与精神病学]