瘦素和瘦素受体基因表达与乳腺癌发生发展的关系  

Associations between expressions of leptin and leptin receptor genes in breast cancer

作　　者：王艳[1] 韩存芝[2] 荆结线[2] 赵先文[2] 杜丽莉[2] 王星[2] 

机构地区：[1]山西医科大学研究生院,太原030001 [2]山西医科大学附属肿瘤医院山西省肿瘤研究所病因室

出　　处：《肿瘤研究与临床》2012年第1期16-19,共4页Cancer Research and Clinic

摘　　要：目的探讨瘦素和瘦素受体基因表达与乳腺癌发生、发展及临床病理特征之间的关系。方法应用免疫组织化学方法检测132例原发性乳腺癌患者、66例乳腺良性病变患者及30例癌旁正常乳腺组织瘦素和瘦素受体基因的表达。结果瘦素及瘦素受体基因在乳腺癌组织中表达的阳性率分别为76．5％（101／132）和70．5％（92／132），显著高于乳腺良性病组[56．1％（37／66）和56．1％（37／66）]、癌旁正常组织[46．7％（14／30）、43．3％（13／30）]，差异有统计学意义（χ^2=8．72，P=0．003；χ^2=4．04，P=0．044；X。10．57，P=0．001；χ^2=7．94，P=0．005）；乳腺癌组织瘦素和瘦素受体基因的表达具有显著相关性（r=0．307，P〈0．05）；乳腺癌组织瘦素与瘦素受体基因的表达在不同年龄、绝经状态、肿瘤大小、分级、组织学类型、远处转移状况、雌激素受体和孕激素受体的表达状况方面差异均无统计学意义（P〉0．05）；但瘦素基因的表达在淋巴结转移患者中阳性率为91．7％，明显高于无淋巴结转移患者的67．9％，二者比较差异有统计学意义（χ^2=10．65，P=0．002）。结论瘦素和瘦素受体基因表达与乳腺癌的发生、发展有密切的关系，瘦素和瘦素受体可能是乳腺癌发生、发展的促进因子。Objective To evaluate the association of expressions of leptin and leptin receptor in breast cancer with tumorigenesis and development and clinicopathologic factors. Methods The expression of leptin and leptin receptor was performed in 132 cases of breast cancer, 66 cases of benign breast lesions, and 30 case＇s of corresponding normal breast tissue by using immunohistochemical methods. Results The expressions of leptin and leptin receptor were 76.5 % （101/132） and 70.5 % （92/132）. It was significantly higher than that in benign breast lesions 56.1% （37/66） and 56.1% （37/66）, and corresponding normal breast tissues 46.7 % （14/30） and 43.3 % （13/30） （X2 = 8.72, P = 0.003, χ^2 = 4.04, P = 0.044, χ^2= 10.57, P = 0.001 and ）（2 = 7.94, P =0.005）. The level of leptin expression showed a significant correlation with the level of leptin receptor （r = 0.307, P 〈 0.05）. The expression of leptin and leptin receptor in breast cancer tissue were not significantly related to ages, menopause, tumor size, classification, pathological type, distant metastasis, ER and PR expression （P 〉 0.05）. The positive rate of leptin in patients with lymph node metastasis was 91.7 %, which was significantly higher than that in patients without lymph node metastasis （67.9 %, χ^2 = 10.65, P = 0.002）. Conclusions The expressions of leptin and leptin receptor have a significant correlation with breast cancer and may have the promoting effect on the carcinogenesis and development of breast cancer.

关 键 词：乳腺癌 瘦素 瘦素受体 临床病理特征 

分 类 号：R737.9[医药卫生—肿瘤]