Na^+/K^+-ATP酶α亚基表达改变对细胞生长的影响  

Influence of Expression Changes of Na^+/K^+-ATPase α-subunit on Cell Growth

作　　者：陈敏敏[1] 李娟[2] 欧阳建[2] 

机构地区：[1]南京医科大学鼓楼临床医学院,南京210009 [2]南京大学医学院附属鼓楼医院血液科,南京210008

出　　处：《医学综述》2012年第5期641-643,共3页Medical Recapitulate

基　　金：国家自然科学基金(30971511)

摘　　要：Na+/K+-ATP酶即钠泵,是Na+、K+离子跨膜转运的载体蛋白,且具有不依赖离子泵的信号转导功能,与特异性配体强心甾类物质(如哇巴因)结合,通过与质膜上邻近蛋白的相互作用,转导信号激发细胞内的级联反应,促进正常细胞的分化与增殖,诱导肿瘤细胞的凋亡。Na+/K+-ATP酶由α、β及γ亚基组成,催化亚基α在Na+/K+-ATP酶行使信号转导功能时起重要作用。α亚基有α1、α2、α3、α4四种亚型,哇巴因对不同亚型的α亚基敏感程度不同。现就哇巴因启动的细胞内信号转导使α亚基表达改变与细胞增殖及凋亡的关系以及α亚基在信号转导机制中的研究进展予以综述。The Na＋/K ＋ -ATPase is not only a transmembrane carrier protein which helps trans- porting Na＋ and K ＋ , but also mediates signal transduction non-relying on ion-pump, through binding with specific ligand cardiac steroids（ such as ouabain） , interacting with the near protein on plasma membrane, transduetion signal stimulating intracellular cascade, promoting normal cell differentiation and proliferation and inducing tumor cell apoptosis. The Na＋/K ＋ -ATPase have several subunits, namely α, β and γ, and the α plays an important role in the signal transduction process. Thecαsuhunit including four subtypes i. e. α1, α2, α3, α4, with which ouabain has different sensitivities. Here is to make a review on the relationship of α-subunit expression and cell proliferation and apoptosis, as well as the molecular mechanisms of α subunit in signal transduetion.

关 键 词：Na+/K+-ATP酶α亚基 哇巴因 细胞增殖 细胞凋亡 信号转导 

分 类 号：R733[医药卫生—肿瘤]