诱导性多能干细胞相关基因Oct4、Sox2、Nanog的研究进展  

Research Progress of Induced Pluripotent Stem Cell Related Genes Oct4,Sox2 and Nanog

作　　者：任建军[1] 贾淑芹[2] 

机构地区：[1]内蒙古医学院附属医院普外科,呼和浩特010050 [2]内蒙古医学院附属医院外科实验室,呼和浩特010050

出　　处：《医学综述》2012年第5期662-664,共3页Medical Recapitulate

基　　金：内蒙古卫生厅2010年医疗卫生科研计划项目(2010038)

摘　　要：诱导性多能干细胞(iPSCs)是将转录因子转入已分化的体细胞中,使其重编程而得到的类似胚胎干细胞(ESCs)的一种细胞类型。iPSCs细胞在形态、基因和蛋白表达、表观遗传修饰状态、细胞倍增能力、类胚体和畸形瘤生成能力、分化能力等方面都与ESCs相似。iPSCs细胞假说一经提出,使得相关基因(如Oct4、Sox2、Nanog等)再次成为基础研究和基因治疗的重要选择。Induced pluripotent stem cells（iPSCs） is a cell type,which are similar to embryonic stern cells（ ESCs）, obtained through transfecting transcription factor to differentiated somatic cell and making it reprogramming, iPSCs cells are similar to ESCs in morphology, gene and protein expression, epigenetic modification, cell multiplication ability, embryoid body and malformation generation capability, and differentiation ability. Once iPSCs hypothesis was put forward, the related genes such as Oct4, Sox2, and Nanog gene once again has become an important choice of basic research and gene therapy.

关 键 词：诱导性多能干细胞 肿瘤干细胞 OCT4 SOX2 NANOG 

分 类 号：R739.6[医药卫生—肿瘤]