阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的影响  

Effect of atorvastatin on carotid atherosclerotic plaques of patients with acute cerebral infarction

作　　者：蔡敏[1] 马璟曦[1] 罗春阳[1] 彭雪梅[1] 

机构地区：[1]重庆市中山医院神经内科,400013

出　　处：《重庆医学》2012年第7期656-657,660,共3页Chongqing medicine

摘　　要：目的观察阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的影响。方法将60例急性脑梗死患者分为对照组(基础治疗,n=30)和治疗组(基础治疗及阿托伐他汀治疗,n=30),共治疗6个月,分别于治疗前、治疗后6个月检测患者血脂和颈动脉内膜中膜厚度(IMT)。结果治疗后6个月,治疗组患者血清总胆固醇(TC)、血清低密度脂蛋白(LDL)、血清三酰甘油(TG)水平及颈动脉IMT较本组治疗前及对照组治疗后6个月明显降低(P<0.05),而其血清高密度脂蛋白(HDL)较对照组明显升高(P<0.05)。结论阿托伐他汀通过稳定颈动脉粥样硬化斑块而对急性脑梗死具有较好的疗效。Objective To observe the effect of atorvastatin on carotid atherosclerotic plaques of patients with acute cerebral infarction.Methods 60 patients with acute cerebral infarction were divided into control group（basic treatment,n=30） and treatment group（basic treatment combined with atorvastatin treatment,n=30）,and were treated for 6 month.Blood lipid and carotid intima-media thickness（IMT） of patients were detected before and 6 month after treatment,respectively.Results 6 month after treatment,levels of serum total cholesterol（TC）,serum low density lipoprotein（LDL）,serum triglyceride（TG） and carotid IMT of patients in treatment were significantly lower than those before treatment in the group and those 6 month after treatment in control group（P0.05）,while the levels of serum high density lipoprotein（HDL） were markedly higher than those in control group（P0.05）.Conclusion Atorvastatin possesses good efficacy on acute cerebral infarction through stabilizing carotid atherosclerotic plaques.

关 键 词：脑梗死 动脉粥样硬化 脂类 血管中膜 阿托伐他汀 

分 类 号：R743.3[医药卫生—神经病学与精神病学]