Rb基因产物与胆囊癌生物学特性的关系  

THE RELATION BETWEEN RETINOBLASTOMA GENE EXPRESSION AND BIOLOGICAL CHARACTERISTICS OF GALLBLADDER CARCINOMA

作　　者：马红兵[1] 王作仁[2] 石景森[2] 刘新莲 

机构地区：[1]西安医科大学第二附属医院肿瘤外科,西安710004 [2]西安医科大学第一临床医学院肝胆外科,西安710004

出　　处：《中国普外基础与临床杂志》2000年第2期87-88,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨Rb蛋白与胆囊癌的肿瘤生物学行为的关系。方法　采用免疫组化SP染色方法检测 41例胆囊癌、7例胆囊腺瘤及 14例胆囊炎石蜡标本Rb蛋白表达水平。结果　Rb蛋白表达阳性率在胆囊癌组为 5 8.7% ,明显低于胆囊炎 ( 10 0 % )及胆囊腺瘤组 ( 10 0 % ) ;且低分化癌组与高、中分化癌组 ,S4 、S5期与S1、S2 及S3 期比较均有显著性差异 (P <0 .0 5 )。结论　Rb蛋白表达与胆囊癌的分化程度。Objective To study the relation between retinoblastoma (Rb) gene expression and biological characteristics of gallbladder carcinoma. Methods The expression of Rb protein in tissues of 41 cases of gallbladder carcinoma, 7 cases of gallbladder papilloma, and 14 cases of cholecystitis were detected by immunohistochemical staining of SP with polyclonal antibody. Results The rate of positive staining was 58.7% in gallbladder carcinoma which was significantly lower than that in cholecystitis and gallbladder papilloma (100%). There was a significant difference of Rb protein expression among the low, moderate and high differentiations and so was between S 5, S 4, S 1, S 2 and S 3 stage ( P <0.05). Conclusion It sugests that expression or non expression of Rb gene is closely related to the malignant potential invasiveness and prognosis of gallbladder carcinoma.

关 键 词：胆囊癌 RB蛋白 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]