子宫内膜癌Ⅱ期术后联合放疗的临床疗效观察  

Outcomes following surgery and adjuvant radiation in stage Ⅱ endometrial carcinoma

作　　者：唐洁[1] 王蕾[1] 

机构地区：[1]湖南省肿瘤医院妇瘤一科,湖南长沙410006

出　　处：《中国现代医学杂志》2012年第3期85-88,共4页China Journal of Modern Medicine

基　　金：湖南省自然科学基金面上项目(No:09JJ5012)

摘　　要：目的探讨子宫内膜癌Ⅱ期手术后辅助放射治疗的疗效及其预后因素。方法对湖南省肿瘤医院妇瘤科2003年1月～2007年6月收治的96例子宫内膜癌Ⅱ期患者进行回顾性研究。全部患者术后辅助直线加速器盆腔野体外照射,其中24例加阴道施源器腔内后装治疗。按患者年龄、肌层浸润、宫旁脉管癌栓、病理类型、病理级别5个观察指标分析与疾病预后的关系。结果患者5年生存率82.3%。肌层浸润、病理类型、宫旁脉管癌栓与疾病预后显著相关(P<0.05),年龄和病理级别与预后无明显相关(P>0.05)。结论子宫内膜癌Ⅱ期手术后辅助放射治疗的疗效肯定,肌层浸润、病理类型、宫旁脉管癌栓是影响子宫内膜癌Ⅱ期生存率的预后因素。[ Objective ] To evaluate the effect in patients treated with surgery and adjuvant radiation for stage II endometrial carcinoma. [Methods ] 96 patients at Hunan Provincial Tumor Hospital for FIGO stage II endometrial carcinoma between January 2003 and June 2007 were retrospectively reviewed. All patients were received adjuvant radiotherapy following surgery. And 24 patients received additional vaginal cuff braehytherapy. Analysis was performed to determine whether there was an association between age, depth of myometrial invasion, parametric vascular invasion, pathologic classification and pathologic grade and prognosis of the disease. [ Results ] The 5-year survival rate was 82.3%. Factors associated with an increased risk for bad prognosis included depth of myometrial invasion, parametric vascular invasion, pathologic classification （P 〈0.05 ）, but not age or pathologic grade（P 〉0.05）. [ Conclusion ] It was effective to combine surgery with adjuvant radiotherapy to treat stage II endometrial carcinoma. Depth of myometrial invasion, parametric vascular invasion and pathologic classification were identified as risk factors for stage II endometrial carcinoma.

关 键 词：子宫内膜癌 手术治疗 放射治疗 预后 

分 类 号：R737.3[医药卫生—肿瘤]