新型喹唑啉酮衍生物的合成  

Synthesis of Novel Quinazolinone Derivatives

作　　者：唐健红[1,2] 史大昕[1] 王秀珍[1] 刘璇[1] 李加荣[1] 

机构地区：[1]北京理工大学化工与环境学院,北京100081 [2]华侨大学化工学院,厦门361021

出　　处：《高等学校化学学报》2012年第3期501-506,共6页Chemical Journal of Chinese Universities

摘　　要：以醛、丙二腈和酮为起始原料,在乙酸铵的催化下一锅合成了2,6-二氰基苯胺衍生物3,化合物3在NaOH催化下,与酮经过分子内Pinner反应到Dimroth重排组合转化,得到新型多取代喹唑啉酮衍生物5.化合物5的结构经IR,1H NMR,13C NMR和MS表征.喹唑啉酮衍生物是一系列药物的重要中间体.2,6-Dicyanoaniline derivatives（3） were synthesized from the multi-component condensation of aldehyde,malononitrile and ketone under the catalysis of ammonium acetate.Then 2,6-dicyanoaniline derivatives reacted with ketones to give mutli-substituted quinazolinone derivatives（5） using sodium hydroxide as catalyst at 100 ℃ or refluxing through intermolecule Pinner reaction via Dimroth rearrangement.The structures of the synthetic compounds were characterized by IR,1H NMR,13C NMR and MS.Quinazolinone derivatives are the important inter-mediate of a series of drugs.

关 键 词：丙二腈 2 6-二氰基苯胺衍生物 喹唑啉酮 环缩合 

分 类 号：O626[理学—有机化学]