氮芥型苦参碱前药的合成与表征  

Synthesis and identification of nitrogen mustard type matrine prodrugs

作　　者：王鹏[1,2] 陶遵威[2] 郑晓辉[1] 张岩[3] 马丽娜[3] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市医药科学研究所,天津300020 [3]天津中医药大学研究生院,天津300073

出　　处：《化学试剂》2012年第3期208-210,215,共4页Chemical Reagents

摘　　要：为了得到活性更好的化疗药剂,以苦参碱和氮芥[N,N-二(2-氯乙基)氨基]互为药效基团,以槐果碱为原料,合成了4个氮芥型苦参碱衍生物,所有化合物未有文献报道,其结构经元素分析、1HNMR和MS测试确证。In order to get more effective chemotherapeutic agents,sophocarpine was utilized as starting material and four target compounds were synthesized using matrine and nitrogen mustard [N,N-bis（2-chloroethyl）amin] as the pharmacophore.The structures of target compounds were confirmed by elemental analysis,1HNMR and MS.

关 键 词：苦参碱 氮芥 抗癌 前药 

分 类 号：R914.5[医药卫生—药物化学] O629.3[医药卫生—药学]